drug interaction may cause sever adverse drug reactions in patients. the high amounts of prescribed medication in hospitalized patients will cause higher incidence of drug interactions. therefore, the study of drug interactions in hospitalized patients seems to be worth. we have, studied drug interaction in internal and surgical units, in kashani hospital in shahrekord. factors included in this...

drug therapy is a complex and important process and because of the importance of drug interactions, especially in in-patients, accompanying problems and obstacles would exist as a result of concomitant use of drugs in these patients. for this purpose 3130 prescription order forms from bou-ali hospital were collected and all potential drug interactions presentwere extracted and evaluated in term...

abstract: warfarin is the most commonly used oral anticoagulant drug in clinical practice with extreme inter and intra-individual variation in pharmacokinetic properties. na valproate, a broad spectrum anticonvulsant agent, is best known for its enzyme inhibition properties and also displacement of protein binding sites. interaction between warfarin and psychotropic drugs including valproate ar...

with the aim of obtaining information about drug-drug interaction (ddi) between acetaminophen and some of antidepressant drugs (fluoxetine, sertraline and nortriptyline), in the present work we studied the electrochemical oxidation of acetaminophen (paracetamol) in the presence of these drugs by means of cyclic voltammetry and controlled-potential coulometry. the reaction between n-acetyl-p-ben...

drug-drug interactions (ddis) can lead to increased toxicity or reduction in therapeutic efficacy. this study was designed to assess the incidence of potential drug interactions (pdi) and rank their clinical value in post coronary care unit (post-ccu) of a teaching hospital in tehran, iran.in this prospective study, three pharmacists with supervision of a clinical pharmacist actively gathered n...

concomitant use of several drugs by icu( intensive care unit) patients is often unavoidable. in these patients, pharmacokinetic drug interactions are very likely. the current study was designed to evaluate these interactions in patients hospitalized in an icu of a teaching hospital in tehran, iran. a questionnaire was designed and used to collect study data. the study was done in the icu of a t...

introduction: interaction between drugs represents a major clinical concern for health care professionals and their patients. patients affected by both type 2 diabetes and epilepsy may be prescribed pioglitazone and an anti-epileptic drug such as phenytoin  concurrently. the aim of this study was to consider the interaction of pioglitazone with phenytoin in an experimental model. according to t...

objective:the purpose of this study was to investigate the effects of piroxicam co-administration with ethanolic stem-bark extract of khaya senegalensis on biomarkers of oxidative stress and gastro-toxicity in wistar rats. materials and methods: thirty healthy male and female albino wistar rats (190-220 g) were grouped into six (n = 5) with designated treatments including: normal saline, piroxi...