In this study, microspheres containing estradiol valerate were prepared by solvent evaporation method using poly (glycolide-co-lactide) (PLGA 50:50) and poly (lactide). The effect of different process variables such as polymer type, drugpolymer ratio, stirring rate, volume of internal phase and temperature of external phase on the morphology, particle size distribution, encapsulation effic...

in this study, microspheres containing estradiol valerate were prepared by solvent evaporation method using poly (glycolide-co-lactide) (plga 50:50) and poly (lactide). the effect of different process variables such as polymer type, drugpolymer ratio, stirring rate, volume of internal phase and temperature of external phase on the morphology, particle size distribution, encapsulation efficiency...

Gastric residence time of oral controlled release system such as microspheres is increase by different techniques such as floating and mucoadhesive system. The objective of present investigation was to formulate floating microspheres of Nateglinide in order to increase gastric residence time, increased bioavailability and to reduce dose frequency of drug molecule. Novel o/w emulsion solvent dif...

Background: Psoriasis is a widespread chronic disease affecting 1-3% of total population and in most cases, treated by topical application corticosteroids. Though, the route very demanding because physicochemical nature diseased stratum corneum so no, single treatment works for every patient. The oral evidence harsh side effects systemic immunosuppression which can be avoided route. Objectives:...

In this paper we describe block algorithms for the reduction of a real symmetric matrix to tridiagonal form and for the reduction of a general real matrix to either bidiagonal or Hessenberg form using Householder transformations. The approach is to aggregate the transformations and to apply them in a blocked fashion, thus achieving algorithms that are rich in matrix-matrix operations. These red...

background: due to difficulty of obtaining a 24h urine (especially in children), a random urine calcium sample is recommended to detect of hypercalciuria. however, recent studies have shown that the urinary calcium/creatinine ratio varies with age and geographic areas. so, the aim of this study was determining the normal value of urinary calcium to creatinine ratio in healthy adolescent’s child...

introduction emerging hypotheses suggest a causal role for prenatal androgen exposure in some cases of autism spectrum disorders (asd). the ratios of the lengths of the bones of the 2nd to the 4th digits (2d:4d) are purported to be markers for prenatal androgen exposure and to be established early in gestation. ratio of second and fourth digits (2d:4d)  is usually used as a proxy for prenatal t...