A simple, rapid, reproducible, accurate and precise Reverse Phase HPLC method was developed for the quantitative simultaneous estimation of Drotaverine hydrochloride and Paracetamol in combined tablet dosage form. Drotaverine hydrochloride is an analog of papaver and is used mainly as an antispasmodic, smooth muscle relaxant. Paracetamol has analgesic and antipyretic activity. The chromatograph...

Drotaverine is considered an inhibitor of cyclic-3',5'-nucleotide-phophodiesterase (PDE) enzymes; however, published receptor binding data also support the potential L-type voltage- operated calcium channel (L-VOCC) blocking effect of drotaverine. Hence, in this work, we focus on the potential L-VOCC blocking effect of drotaverine by using L-VOCC-associated functional in vitro models. According...

Objectives: To compare the duration of labour and rate of cervical dilatation with drotaverine hydrochloride and valethamate bromide in first stage of labour. : Sixty consecutive uncomplicated primigarvida with spontaneous onset of labour, at term gestation with vertex Materials and methods presentation were selected and randomized into two groups of 30 each. One group received drotaverine hydr...

Purpose: Prolong labour contributes to increased perinatal and maternal morbidity. Inhibitory impulses in the form of spasm often impair the dilatation of cervix and prolong the duration of labour. This study was undertaken to compare the effect of Tramadol Hydrochloride And Drotavarine Hydrochloride on duration of labour and rate of cervical dilatation and compare it with control group. Method...

OBJECTIVE To compare efficacy and tolerability of drotaverine 80 mg and ibuprofen 400 mg in patients with primary dysmenorrhoea. MATERIALS AND METHODS Nine-month, multicenter (11 study centers in Poland), randomised, double-blind, phase III study, conducted in two parallel group, included 345 women between the ages of 18 and 35, suffering from primary dysmenorrhoea with presence of moderate t...

OBJECTIVE To evaluate the analgesic efficacy and safety of intramuscular drotaverine hydrochloride vs diclofenac sodium in treatment of acute renal colic. METHODS We conducted a randomized, single-blind study comparing single intramuscular doses of drotaverine hydrochloride (80 mg) vs diclofenac sodium (75 mg) on 100 patients (50 in each arm) presenting to the emergency department (ED) with r...

Two simple, accurate and reproducible spectrophotometric methods; Q analysis and first order derivative method have been described for the simultaneous estimation of drotaverine hydrochloride and paracetamol in combined tablet dosage form. Absorption maxima of drotaverine hydrochloride and paracetamol in distilled water were found to be 303.5 nm and 243.5 nm respectively. Beer's law was obeyed ...

Three simple spectrophotometric methods have been developed for simultaneous estimation of Drotaverine HCl and Omeprazole from tablet dosage form. Method-I involves, formation of Q-absorbance equation at 306.0 nm (isoabsorptive point) and 229.5 nm (lmax of drotaverine); simultaneous equation method (Method-II) and Method-III is the multicomponent mode of analysis in which the inbuilt software c...

A simple high-performance liquid chromatographic method with ultraviolet detection is proposed for the estimation of diclofenac potassium and drotaverine hydrochloride in human plasma. Liquid-liquid extraction was carried out with a mixture of dichloromethane-isopropyl alcohol (80:20, v/v). Chromatographic separation of the analytes and internal standard was achieved on an analytical 250 × 4.6 ...

OBJECTIVE To evaluate the efficacy and safety of Drotaverine hydrochroride in children with recurrent abdominal pain. DESIGN Double blind, randomized placebo-controlled trial. SETTING Pediatric Gastroenterology clinic of a teaching hospital. PARTICIPANTS 132 children (age 4-12 y) with recurrent abdominal pain (Apley Criteria) randomized to receivedrotaverine (n=66) or placebo (n=66) orall...