نتایج جستجو برای: Double-Strandbreak (DSB)

تعداد نتایج: 241478  

Amaneh Mohammadi, Mana Oloomi, Manabu Fukumoto, Mehryar Habibi Roudkenar, Saeid Bouzari, Taisuke Baba, Yoshikazu Kuwahara,

Background: Immunotoxins are comprised of both the cell targeting and the cell killing moieties. We previously established a new immunotoxin, i.e. Shiga toxin granulocyte macrophage-colony stimulating factor (StxA1-GM-CSF), comprises of catalytic domain of Stx, as a killing moiety and GM-CSF, as a cell targeting moiety. In this study, the ability of the immunotoxin to induce apoptosis and dou...

2015
Nicola Manfrini Michela Clerici Maxime Wery Chiara Vittoria Colombo Marc Descrimes Antonin Morillon Fabrizio d'Adda di Fagagna Maria Pia Longhese Jessica K Tyler

Emerging evidence indicate that the mammalian checkpoint kinase ATM induces transcriptional silencing in cis to DNA double-strand breaks (DSBs) through a poorly understood mechanism. Here we show that in Saccharomyces cerevisiae a single DSB causes transcriptional inhibition of proximal genes independently of Tel1/ATM and Mec1/ATR. Since the DSB ends undergo nucleolytic degradation (resection) ...

Journal: :iranian biomedical journal 0
مهریار حبیبی رودکنار mehryar habibi roudkenar سعید بوذری saeid bouzari yoshikazu kuwahara آمنه محمدی روشنده amaneh mohammadi taisuke baba مانا علومی mana oloomi

background: immunotoxins are comprised of both the cell targeting and the cell killing moieties. we previously established a new immunotoxin, i.e. shiga toxin granulocyte macrophage-colony stimulating factor (stxa1-gm-csf), comprises of catalytic domain of stx, as a killing moiety and gm-csf, as a cell targeting moiety. in this study, the ability of the immunotoxin to induce apoptosis and doubl...

Journal: :Scientific Reports 2021

Abstract Ulcerative colitis (UC) is a DNA damage-associated chronic inflammatory disease; the double-strand break (DSB) repair pathway participates in UC-associated dysplasia/colitic cancer carcinogenesis. The DSB/interferon regulatory factor-1 (IRF-1) can induce PD-L1 expression transcriptionally. However, association of PD-L1/DSB/IRF-1 with sporadic colorectal (SCRC), and cancer, remains elus...

Journal: :Cell 2009
Kara A. Bernstein Rodney Rothstein

Double-strand break (DSB) repair is critical for maintaining genomic integrity and requires the processing of the 5' DSB ends. Recent studies have shed light on the mechanism and regulation of DNA end processing during DSB repair by homologous recombination.

Hosein Azimian, Mahdieh Dayyani Mahmoud Mahmoudi Mohammad Taghi Bahreyni Toossi,

Introduction: A high risk for development of severe side effects after radiotherapy may be correlated with high cellular radiosensitivity. To enhance radiation therapy efficiency a fast and reliable in-vitro test is desirable to identify radiosensitive patients. The aim of present study was to identify the mechanism of radiation induced DNA double-strand breaks (DSBs) and DSB r...

Journal: :International journal of radiation oncology, biology, physics 2010
Claudia E Rübe Andreas Fricke Ruth Schneider Karin Simon Martin Kühne Jochen Fleckenstein Stefan Gräber Norbert Graf Christian Rübe

PURPOSE To evaluate, in a pilot study, the phosphorylated H2AX (γH2AX) foci approach for identifying patients with double-strand break (DSB) repair deficiencies, who may overreact to DNA-damaging cancer therapy. METHODS AND MATERIALS The DSB repair capacity of children with solid cancers was analyzed compared with that of age-matched control children and correlated with treatment-related norm...

Journal: :Plant physiology 2003
Tzvi Tzfira Leah Renée Frankman Manjusha Vaidya Vitaly Citovsky

Agrobacterium tumefaciens-mediated genetic transformation involves transfer of a single-stranded T-DNA molecule (T strand) into the host cell, followed by its integration into the plant genome. The molecular mechanism of T-DNA integration, the culmination point of the entire transformation process, remains largely obscure. Here, we studied the roles of double-stranded breaks (DSBs) and double-s...

ژورنال: سنجش و ایمنی پرتو 2020

Radiotherapy using various beams is one of the methods for treating cancer, Hadrons  used   to  treat cancers  that  are  near critical organs. The most important part of the cell that is damage by ionizing radiation is DNA. In this study, damages induced in the  genetic material of  living cells (DNA) defined by  the  atomic model from the  protein data bank (PDB) have been studied by  radiati...

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