BACKGROUND The geographic map of cancer prevalence differs due to environmental and dietary factors in various populations. High prevalence of a number of cancers in some regions is thought to be attributed to local dietary habits. Dorema aucheri (Bilhar) is used commonly as an herbal medicine in some regions including Iran. The aim of this study was to evaluate whether Dorema aucheri has carci...

PURPOSE In the present study cytotoxic effects of the alcoholic extract of Dorema Glabrum seed on viability of WEHI-164 cells, mouse Fibrosarcoma cell line and L929 normal cells were compared with the cytotoxic effects of Taxol (anticancer and apoptosis inducer drug). METHODS To find out the plant extract cytotoxic effects, MTT test and DNA fragmentation assay, the biochemical hallmark of apo...

We aimed to investigate the apoptotic effects of the methanolic extract of Dorema glabrum seed on WEHI-164, cancerous cells in comparison with L929, normal cells and compared them with the cytotoxic effects of Taxol. So, MTT test and DNA fragmentation assay were performed on cultured and treated cells. Also electrophoresis which was followed by immunoblotting was done to survey the production o...

Dear Editor, Seven species have been reported in the genus Dorema, family Umbelliferae, in the flora of Iran, among which two are endemic: D. aucheri Boiss. and D. ammoniacum D. Don. 1 In Iranian traditional medicine, Dorema aucheri has been employed as stimulant, nervonic, antispasmodic, bronchodilator, expectorant, kidney stone repellent, emmenagogue and analgesic for visceral pain. This plan...

Original meiotic or both and mitotic chromosome numbers are reported for ten endemic one non species in nine vascular plant families from Iran. The of Acantholimon schahrudicum, A. truncatum, Anthochlamys multinervis, Campanula perpusilla, Cousinia calcitrapa var. interrupta, Dorema ammoniacum, Euphorbia gedrosiaca, Hyocyamus orthocarpus were determined the first time. counts Astrodaucus persic...

Abstract Dorema (Apiaceae) includes 12 species distributed in the Irano-Turanian region. The genus differs from other genera of subfamily Apioideae having paniculate inflorescences with simple umbels. Recently, molecular phylogenetic analyses placed six Dorema, including generitype, Ferula , thus subsuming former into synonymy latter. remaining congeners have not been yet included analyses. Her...

BACKGROUND Dorema aucheri is a plant of Apiaceae family which is used widely in some states of Iran. Different extracts and essential oil of Dorema species contain flavonoids and cumarin compounds which have anti-hypertensive, cholesterol- and triglycerides-lowering properties. This study was undertaken to evaluate the genotoxic properties of hydroalcoholic and aqueous extracts of D. aucheri on...

Some Dorema species are used in Persian traditional medicine. In the present study the total extract from the roots of Dorema hyrcanum Koso-Pol. was investigated for its in-vitro (pLDH assay) and in-vivo (Peters' 4-days suppressive test) antiplasmodial effects and assessed for cytotoxicity against the normal cell line MDBK (MTT test). The IC50 values for a chloroquine- sensitive (3D7) and a chl...

this study investigated the anticonvulsant activity and possible mechanism of action of an aqueous solution of dorema ammoniacum gum (dag) which has been used traditionally in the treatment of convulsions.in this study, the anticonvulsant activity of dag was examined using the pentylentetrazole (ptz) model in mice. thirty male albino mice were divided randomly and equally to 5 groups, and pretr...