Acupuncture can be used to treat various nervous system diseases. Here, 168 vascular dementia patients were orally administered donepezil hydrochloride alone (5 mg/day, once a day for 56 days), or combined with acupuncture at Shenting (DU24), Tianzhu (BL10), Sishencong (Extra), Yintang (Extra), Renzhong (DU26), Neiguan (PC6), Shenmen (HT7), Fengchi (GB20), Wangu (GB12) and Baihui (DU20) (once a...

Actavis and Adamas Pharmaceuticals, Inc., announced that the U.S. Food and Drug Administration has approved the New Drug Application for NamzaricTM for the treatment of moderate to severe dementia of the Alzheimer’s type in patients stabilized on memantine hydrochloride and donepezil hydrochloride. Namzaric will be available in two dosage strengths: 28/10 mg (memantine extended release/donepezi...

Introduction: Donepezil (DON), an Acetylcholinesterase Inhibitor (AChEI), is widely used in the treatment of Alzheimer’s Disease (AD). The current study aimed at evaluating the effect of donepezil hydrochloride on pyramidal neuron response in CA1 region of a rat model of AD. Methods: In the current experimental study, adult male Wistar rats were randomly divided into four groups: Nucleus Basal...

the present study deals with the formulation and evaluation of chitosan nanoparticles containing donepezil hydrochloride for the targeted delivery to the brain. nanoparticles were prepared by ionic gelation method using sodium tripolyphos-phate (tpp) as a cross linking agent followed by sonication. nanoparticles were obtained in the average size ranging from 116.8 to 227.5 nm. particle morpholo...

A sensitive, isocratic reversed-phase high performance liquid chromatographic method involving fluorescence detection was developed for the determination of donepezil hydrochloride in tablets and in human plasma. Pindolol was used as an internal standard. Good chromatographic separation was achieved by using an analytical column C18. The system operated at room temperature using a mobile phase ...

OBJECTIVE To determine the efficacy of donepezil hydrochloride for the treatment of Alzheimer disease in patients drawn from clinical practice. DESIGN Two-center, randomized, placebo-controlled, double-masked crossover study. SETTING Memory disorders units at Massachusetts General and Brigham and Women's hospitals, Boston. PATIENTS Sixty individuals (30 men and 30 women; mean +/- SD age, ...

A stability indicating HPLC method for the estimation of donepezil hydrochloride in tablets was developed and validated. Donepezil hydrochloride is a reversible inhibitor of acetylcholinesterase, indicated for the treatment of mild to moderate dementia of the Alzheimer’s type. The HPLC method was performed with a reversed phase C18 column (250 mm X 4.6 mm id, 5mm particle size), detection at 23...

Donepezil is used worldwide for the treatment of Alzheimer’s disease, where it is used to increase cortical acetylcholine. We present a simple liquid chromatography-tandem mass spectrometry (LC-MS/MS) method developed and validated for the quantification of Donepezil in Human Plasma. Quetiapine was used as the internal standard. The simple and cost effective Liquid-Liquid Extraction method is a...

AIM The aim of this study was to examine the pharmacokinetics of donepezil HCl and ketoconazole separately, and in combination, following administration of single and multiple oral doses. METHODS This was an open-label, randomized, three-period crossover study in healthy volunteers (n=21). During each treatment period, subjects received single daily doses of either donepezil HCl (5 mg), ketoc...