Dithranol was introduced into anti-psoriatic therapy in 1916, but the principle of its activity remains unkown with regard to the quantitative aspects of its efficacy e.g. in enzyme inhibition, D N A interaction and interference with lipid metabolism. In vitro experiments have indicated that dithranol irreversibly inhibits glucose-6-phosphate-dehydrogenase (EC 1.1.1.49) [10] and the incorporati...

Although the precise causes of psoriasis remain to be elucidated, psoriasis has been known as a disorder in which factors in the immune system, enzymes and other biochemical substances that regulate skin cell division are functionally imbalanced, thereby resulting in rapid proliferation of keratinocytes and incomplete keratinization. The expression of candidate genes such as E2A and caspa...

The chemiluminescence arising from the reaction of bis(2,4,6-trichlorophenyl)oxalate with hydrogen peroxide in the presence of dithranol has been studied. The influence of concentration of peroxyoxalate, hydrogen peroxide, dithranol, catalyst and temperature on the resulting chemiluminescence was investigated. The kinetic parameters for the peroxyoxalate-chemiluminescence of dithranol were eval...

The precise causes of psoriasis, a chronic skin disorder characterized by hyperproliferation of keratinocytes and incomplete keratinization, are unclear. It is known that expression of helix-loop-helix transcription factor Id1, which functions as an inhibitor of differentiation, is upregulated in psoriatic skin. We investigated the effect of the antipsoriatic drug dithranol on mRNA and protein ...

Aim of the study : To compare the efficacy and tolerability of various topical therapies like short contact Lipsomal dithranol ointment, 0.1% Betamethasone valerate ointment and liquid paraffin for psoriasis. Materials and Methods: This study was conducted in dermatology department of a tertiary hospital and a total of sixty patients who attended the Psoriasis clinic were randomly allocated to ...

A simple, specific, accurate, precise and reproducible method has been developed and validated for the estimation of Dithranol in lipid nanoparticle by RP-HPLC method. RP-HPLC estimation of dithranol in prepared formulation was performed using Phenomenex ODS 5μ, C18 column and Acetonitrile: Methanol: Buffer (20:20:60) as mobile phase which had shown sharp peak when detected at 258 nm. The linea...

Abstract Background Dithranol, a standard drug for psoriasis, has lured keen attention by virtue of its antioxidant, anti-proliferative and anti-inflammatory activities. However, poor stability solubility critically impair the formulation design, evaluation administration. To improve these issues, dithranol was encased in ?-cyclodextrin nanosponges using solvent evaporation technique. Previousl...

Dithranol is a potent agent in treating psoriasis but its adverse effects on intact skin have limited its usage. There are many proposed mediators for its adverse effects including prostaglandins, histamine, platelet activating factor and free radicals. In this study we examined the effect of different agents (diazepam, terfenadine, indomethacin and garlic extract) on dithranol-induced skin dam...

The present study was planned to improve the stability of dithranol using solid dispersions (SD). Two different SD at a 1:9 ratio of dithranol/excipient were prepared: one of them using glyceryl behenate as excipient and the other using a mixture of argan oil with stearic acid (1:8 ratio) as excipient. Pure dithranol and SD of dithranol were incorporated in an oil-in-water cream and in a hydrop...

Dithranol is one of the oldest and most efficient drugs used in treatment psoriasis. One challenges with using dithranol its photostability, because it easily degrades when exposed to light. This study investigated potential coaxial core-sheath PCL/PVA nanofibers as a dual-functional system for enhancing photostability remote-controlled drug delivery psoriasis therapy. We have shown that titani...