global tuberculosis (tb) report (2013) has revealed that an estimated 8.6 million people developed tb of which, india accounts for almost 26% of the cases. these estimates clearly suggest that the country’s efforts to achieve millennium development goal 6 by 2015 have not delivered the desired output. in india, the tb prevention and control activities are supervised and implemented under the re...

BACKGROUND Tuberculosis remains a major public health problem in Ethiopia. In 2010 the TB treatment regimen was shortened from 8 to 6-months treatment. With this new regimen, the full course of treatment should be taken under Directly Observed Therapy (DOT) unlike the 8-month regimen where TB patients were only observed during the intensive phase, this has not been tried before and may be diffi...

The total number of new tuberculosis (TB) cases notified in Singapore among citizens, permanent residents and foreigners rose by 46% from 2004 to 2010. During this period, the proportion of foreigners increased from 29% to 47% of the total case burden. In 2008, the TB incidence rate among Singapore citizens and permanent residents increased for the first time in ten years, despite the on-going ...

Global Tuberculosis (TB) report (2013) has revealed that an estimated 8.6 million people developed TB of which, India accounts for almost 26% of the cases. These estimates clearly suggest that the country’s efforts to achieve Millennium Development Goal 6 by 2015 have not delivered the desired output. In India, the TB prevention and control activities are supervised and implemented under the Re...

BACKGROUND We investigated the epidemiology and prevalence of potential risk factors of tuberculosis (TB) recurrence in a population-based registry cohort of 8084 TB cases between 1995 and 2013. METHODS An episode of recurrent TB was defined as a case re-registered in the National Infectious Disease Register at least 360 days from the date of the initial registration. A regression model was u...

The need for better drugs to treat tuberculosis has never been greater. Despite insufficient funding for discovery research, intensive efforts have been made to find and develop new lead compounds capable of reducing the duration of the present treatment known as DOTS (directly observed therapy short course), from 6 to under 4 months. This minireview describes the progress achieved during the l...

We measured hair and plasma concentrations of isoniazid among sixteen children with tuberculosis who underwent personal or video-assisted directly observed therapy and thus had 100% adherence. This study therefore defined typical isoniazid exposure parameters after two months of treatment among fully-adherent patients in both hair and plasma (plasma area under the concentration-time curve, AUC,...

The recent increase in the notifications of tuberculosis infections has focused the attention of healthcare professionals on reasons for the disease's resurgence. This article describes how directly observed therapy and an enlightened approach to health promotion for groups of people perceived as being at risk, could prevent further increases in incidence.

CONTEXT Immigration is a major force sustaining the incidence of tuberculosis (TB) in the United States. OBJECTIVE To describe trends and characteristics of foreign-born persons with TB and the implications for TB program planning and policy development. DESIGN, SETTING, AND SUBJECTS Descriptive analysis of US TB surveillance data from case reports submitted from 1993 to 1998. MAIN OUTCOM...