Cohesive energy densities (C(w,MLA)/J cm(-3)) for ion-pair complexes (MLA: M(+) = Li(+) to Cs+; w: water) with six crown ethers (L), such as 18-crown-6 ether (18C6), benzo-18C6, and dibenzo-24-crown-8 one, and A(-) = picrate were calculated at 298 K by a procedure that uses either (i) an equation rearranged from that underlying log K(D,MLA)-vs.-log K(D,L) plots or (ii) intercepts of their plots...

α-Methylacyl-CoA racemase (AMACR; P504S) regulates branched-chain fatty acid degradation, activates Ibuprofen and is a recognised cancer drug target. A novel, facile colorimetric assay was developed based on elimination of 2,4-dinitrophenolate. The assay was used to test 5 known inhibitors, determining IC50 and Ki values, reversibility and characterizing irreversible inhibition.

In the title salt, C(5)H(8)N(3) (+)·C(7)H(3)N(2)O(7) (-), the pyridine N atom of the 3,4-diamino-pyridine mol-ecule is protonated. The 3,5-dinitro-salicylate anion shows whole-mol-ecule disorder over two orientations with a refined occupancy ratio of 0.875 (4): 0.125 (4). In the crystal, the cations and anions are connected by inter-molecular N-H⋯O and C-H⋯O hydrogen bonds, forming a three-dime...

A new series of noncyclic ionophores containing two to four furan units (Ia to IIIb) i.e. 1,1-difurylethane (Ia), 2,5-bis(methylfurfuryl)furan (IIa) and 1,1’ ethyledenebis[5-(methylfurfuryl)furan] (IIIa), 2,2-difurylpropane (Ib), 2,5-bis (dimethylfurfuryl)furan(IIb), 2,2’-isopropylidenebis[5-(dimethylfurfuryl)furan] (IIIb) have been synthesized by the condensation of furan with acetaldehyde and...

a new series of noncyclic ionophores containing two to four furan units (ia to iiib) i.e. 1,1-difurylethane (ia), 2,5-bis(methylfurfuryl)furan (iia) and 1,1’ ethyledenebis[5-(methylfurfuryl)furan] (iiia), 2,2-difurylpropane (ib), 2,5-bis (dimethylfurfuryl)furan(iib), 2,2’-isopropylidenebis[5-(dimethylfurfuryl)furan] (iiib) have been synthesized by the condensation of furan with acetaldehyde and...