in present paper a simple procedure for the synthesis of enaminones without catalyst from 1,3-diketones that reacted with primary or secondary amines in ethanol as solvent, as well as the reaction of enaminones with unsaturated esters such as dimethyl acetylene dicarboxylate are reported.

In present paper a simple procedure for the synthesis of enaminones without catalyst from 1,3-diketones that reacted with primary or secondary amines in ethanol as solvent, as well as the reaction of enaminones with unsaturated esters such as dimethyl acetylene dicarboxylate are reported.

Intermolecular [2+2+2] cycloaddition reaction employing an air-stable ruthenium perchloro-cyclobutenonyl complex as a catalyst is reported. A series of internal alkynes were incorporated with dimethyl acetylene-dicarboxylate in a ratio of 1:2 to give various substituted benzenes in high yield and high chemoselectivity.

New series of 2,3-disubstituted quinazolin-4(3H)one were synthesized via the reaction of the readily obtainable 2-thioxo-3-phenyl-quinazolin-4(3H)one 1 with ethyl chloroacetate followed by hydrazinolysis to afford the hydrazide 3 which allowed to react with different electrophilic reagents such as carbon disulphide, phenyl isothiocyanate, β-diketones, anhydrides, acrylonitrile, ethyl cinnamate,...

Recently, we have reported convenient methods for the synthesis of five-membered heterocycles by the use of 1,3-dipolar cycloaddition reactions.1,2) The introduction of chirality into the resulting cycloadducts was required for further application of these methods. Asymmetric synthesis or optical resolution by the use of enzymes is an effective method for obtaining chiral synthons, and pig live...

Synthesis of novel 5-methylidene-1,2,3,5-tetrahydro[2,1-b]-quinazoline derivatives 2-4 with potential biological activities mediated by alpha-adrenergic and/or imidazoline receptors was performed by reacting 2-chloro-4,5-dihydroimidazole (1) with the corresponding 2-aminoacetophenones. Compound 2, which incorporates an enamine moiety, underwent a 1,3-dipolar cycloaddition reaction with the appr...

Abstract: The reactive 1:1 intermediate produced in the reaction between cyclohexyl isocyanide and electron- deficient acetylenic esters or dimethyl acetylene dicarboxylate was trapped by 2-cyano-N-(Aryl) acetamides to provides highly functionalized oxopyridine (potential synthetic and pharmaceutical interest )  in  acetonitrile under mild reaction conditions at ambient temperature after 24 h ...

A systematic study of the addition of various 1,2-acyclic diones to activated acetylenic esters catalyzed by pyridine under mild conditions is described. This reaction provides a new protocol for the stereoselective synthesis of 1,2-diaroyl maleates. The exclusive formation of the cis isomer is especially noteworthy. This reaction occurs through the initial generation of a pyridine-dimethyl ace...