Aim: Dimedone , gamma pyrone and barbituric acid and their derivatives have also been found to be very important from their application point of view. Thus our aim was to prepare more derivatives from them. Method : Dimedone , gamma pyrone and barbituric acid have been treated with dimethyl sulphoxide and acetic anhydride reagent under varying temperature conditions in order to get more compoun...

Protein sulfenic acids are reactive, reversibly oxidized cysteinyl residues with roles in redox catalysis and regulation. Detection and quantification of these species in proteins is accomplished through chemical modification by reagents such as 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole (NBD chloride), 2-nitro-5-thiobenzoate (TNB), dimedone, or derivatives of dimedone, followed by UV-visible spec...

One-pot three-component cyclo-condensation reaction of bis(indole-2,3-diones) with dimedone, 3-methyl-1H-pyrazol-5(4H)-one, or 6-aminouracil in boiling acetic acid afforded bis-spirocyclic oxindole...

The reversible oxidation of protein cysteine residues (Cys-SH) is a key reaction in cellular redox signaling involving initial formation of sulfenic acids (Cys-SOH), which are commonly detected using selective dimedone-based probes. Here, we report that significant portions of dimedone-tagged proteins are susceptible to cleavage by DTT reflecting the presence of perthiosulfenic acid species (Cy...

An efficient one pot coupling of aldehydes, dimedone, ammonium acetate and ethyl acetoacetate by using catalytic amount of enneamolybdomanganate(IV) is reported. Various polyhydroquinoline derivatives have been prepared in high yields and comparatively less reaction time.

Reactive methylene group at C2 position in dimedone plays an important role in the synthesis of a variety of organic ligands. Condensed compounds 3, 5, 7 were synthesized by reaction with dimedone and different aromatic aldehydes. Synthesized condensed compounds 3, 5 and 7 were on reaction with hydroxyl amine hydrochloride to yield oximes ligands 8, 9 and 10 respectively. The synthesized oxime ...

Cysteine sulfenic acids in proteins can be identified by their ability to form adducts with dimedone, but this reagent imparts no spectral or affinity tag for subsequent analyses of such tagged proteins. Given its similar reactivity toward cysteine sulfenic acids, 1, 3-cyclohexadione was synthetically modified to an alcohol derivative and linked to fluorophores based on isatoic acid and 7-metho...

Symmetrical and non-symmetrical diimines derived from dimedone were synthesized by the reaction of their corresponding enaminothiones with primary amines. The synthesized compounds were characterized using micro analytical data and NMR spectroscopy. Theoretical calculations by B3LYP/6-31G(d,p) level of theory show that the enolic form is the most stable within the possible tautomeric forms of t...