conclusions lidocaine-meperidine-diltiazem gel provides significantly better pain control than lidocaine-diltiazem gel and lidocaine gel alone during transrectal ultrasound guided prostate biopsy and probe insertion. this mixture gel is safe, easy to administer and well accepted by patients. results the mean of visual analog pain scale was 4.5 in group a, 3.5 in group b, and 2.0 in group c duri...

cyclosporine (csa) is a drug that has been used for prevention of kidney transplant rejection for many years. diltiazem with the inhibition of cyclosporine metabolism and clearance will increase csa concentration and csa dose can be decreased. the aim of this study was the evaluation of diltiazem effect on csa dose adjustment with respect to c2. forty stable renal transplant patients who were r...

       Cyclosporine (CsA) is a drug that has been used for prevention of kidney transplant rejection for many years. Diltiazem with the inhibition of cyclosporine metabolism and clearance will increase CsA concentration and CsA dose can be decreased. The aim of this study was the evaluation of diltiazem effect on CsA dose adjustment with respect to C2. Forty stable renal transplant p...

PURPOSE We investigated a potential hepatoprotective role of d-cis diltiazem, l-cis diltiazem, thiamine and the combination d-cis diltiazem and thiamine against lipid peroxidation in a piglet liver microsomal model. A modified in vitro dichlorofluorescein assay was developed to assess the extent of peroxidative damage induced by reactive oxygen species in the piglet liver microsomal fraction. ...

the goal of this study was to determine the effects of the l-type calcium channel blockers verapamil and diltiazem on the currents of voltage-gated potassium channel (fkv1.4δn), an n-terminal-deleted mutant of the ferret kv1.4 potassium channel. measurements were made using a two electrode voltage clamp technique with channels expressed stably in xenopus oocytes. the fkv1.4δn currents displayed...

We have studied the ability of the calcium channel antagonist diltiazem to inhibit and reverse the porcine malignant hyperpyrexia (MH) syndrome. Pretreatment with diltiazem modified an MH response. Treatment with diltiazem was partially effective against a mild (or early) MH response. Diltiazem should not be considered to be an effective therapeutic agent for MH and should not displace the use ...

BACKGROUND Diltiazem hydrochloride is a widely used calcium channel blocking agent. While a few cases of diltiazem-associated photosensitivity have been reported, no cases of photodistributed hyperpigmentation are known. OBSERVATION Four cases of photodistributed hyperpigmentation associated with the long-acting formulation of diltiazem hydrochloride (Cardizem CD) are presented. All patients ...

The Multicenter Diltiazem Postinfarction Trial (MDPIT) reported no consistent diltiazem effect on new or worsened congestive heart failure (CHF) during 12-52 months' follow-up after acute myocardial infarction. This was puzzling in light of the observation that patients with findings suggesting left ventricular dysfunction (LVD) at baseline on diltiazem had more cardiac events (cardiac mortalit...

AIMS Triazolam, a triazolobenzodiazepine hypnotic agent, is metabolized by CYP3A4. Diltiazem is an inhibitor of this isozyme. The aim of this study was to determine if diltiazem affects plasma concentrations of triazolam in humans. METHODS We investigated the interaction between triazolam and diltiazem in a randomized, three-phase crossover study. Seven healthy male volunteers received orally...