نتایج جستجو برای: Dihydroquinazolinone
تعداد نتایج: 13 فیلتر نتایج به سال:
Provided herein are novel nitrogen-containing 2,3-dihydroquinazolinone compounds as Nav1.8 inhibitors, pharmaceutical compositions, use of such in treating pain and cardiovascular diseases, processes for preparing compounds.
Introduction: By development of bacterial drug-resistance to traditional antibacterial drugs and fungal infections, the need to design, synthesis, and use of new and effective antibacterial and antifungal drugs is increased. Quinazolinone derivatives are heterocyclic compounds with nitrogen atoms that have pharmacological properties such as anti-bacterial, anti-tumor, anti-inflammatory and an...
An efficient protocol for the synthesis of 2,3-dihydroquinazolinone derivatives from substituted 2-aminobenzamides and carbonyl analog catalyzed by natural-based 5,5’-indigodisulfonic acid has been developed with good to excellent yields. Compared reaction conditions reported before, use eco-friendly recyclable catalysts mild are major advantages present method.
A gold-catalyzed cascade process for the synthesis of dihydroquinazolinone scaffolds was developed. series gold catalysts were screened this tandem transformation, and (PPh3)AuCl/AgOTf catalyst combination found to be best system. This method is characterized by good yields, high regioselectivity, broad substrate scope. also applicable tetracyclic dihydroquinazolinones seven-membered ring-fused...
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