We have synthesized four novel derivatives of podophyllotoxin, the chalcone derivatives namely 2benzylidene-6,7-dimethoxy-4-phenyl-3,4-dihydro-2H-naphthalen-1-one (4a), 2-benzylidene-5,7-dichloro-6hydroxy-4-phenyl-3,4-dihydro-2H-naphthalen-1-one(4b), and the amino-thiazolyl derivatives namely7,8dimethoxy-5-phenyl-4,5-dihydro-naphtha[1,2-d] thiazol-2-yl amine (5a) and 2-amino-6,8-dichloro-5-phen...

Abstract Inverse electron-demand Diels–Alder additions (iEDDA) between 1,2,4,5-tetrazines and suitable unsaturated dienophiles such as olefins, alkynes, or enol ethers provide facile access to pyridazines. Herein the use of cyclic ether derivatives for preparing pyridazines bearing 2-hydroxyethyl, 3-hyproxypropyl, 3-oxopropyl substituents at 4-position is disclosed second order rate constants r...

1. 7- and 12-Methylbenz[a]anthracene were converted by rat-liver homogenates into the corresponding hydroxymethyl derivatives, products that are probably the 8,9-dihydro-8,9-dihydroxy and the 5,6-dihydro-5,6-dihydroxy derivatives, and a number of phenolic products. 2. Both hydrocarbons were converted into glutathione conjugates; that from 7-methylbenz[a]anthracene was also formed, together with...

Environmentally friendly synthetic methods were developed for the selective preparation of new 2,3-dihydro-1,4-thiaselenine derivatives in high yields based on reactions 2-bromomethyl-1,3-thiaselenole with alcohols and water at room temperature. The reaction was accompanied by a rearrangement ring extension, leading to six-membered heterocyclic compounds, family 2-organyloxy-2,3-dihydro-1,4-thi...

Dihydro furan derivatives are potentially bioactive hence we started working on it prepared them from 2-(4-nitrophenyl)-2-oxoethyl 2-phenylacetate, reducing and adding substituted carboxylic acids with EDCI, HOBt leads to the titled compounds.

In this work, some 2-nonsubstituted/2-methyl-/2-(2-acetyloxyethyl)-6-[4-(substituted pyrrol-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone, derivatives and 2-nonsubstituted/2-methyl- 4-[4-(substituted pyrrol-1-yl)phenyl]-1(2H)-phthalazinone derivatives were synthesised by reacting hexan-2,5-dion or 1-aryl-3-carbethoxypent-1,4-diones with corresponding 2-substituted/nonsubstituted 6-(4'-aminophenyl...

Several 5-alkyl, 5-alkenyl, 5-iso-alkyl, 5-halo, 5-aminomethyl and 5-carboxy derivatives of S-DABOs (dihydro-alkyl (or cyclo-alkyl)thio-benzyloxopyrimidines), DATNOs (dihydro-alkylthionaphthylmethyl-oxopyrimidines) and F2-S-DABOs (dihydro-alkyl (or cyclo-alkyl)thio-2,6-difluorobenzyl-oxopyrimidines) have been prepared and tested as anti-HIV-1 agents. S-DABO derivatives bearing at C-6 position m...

A one-pot synthesis ofdimethyl-{3-methyl-2-[(alkoxycarbonyl) anilino]-2,3-dihydro-1Himidazol-1-yl)}-2-butenedioatesanddimethyl-2-[(alkoxycarbonyl)anilino]-2-butenedioates derivatives via reactions between dimethyl acetylenedicarboxylate,1-methylimidazoleand N-phenylcarbamates is described. The mild reaction condition, simple mixing of the starting materials and good yields exhibit the synthetic...

In the further research and synthesis of highly bioactive 3-methylrhodanine derivatives, preparation benzylidene rhodanines followed by bicyclization to form pyrazole compounds has been undertaken. Using a convenient simple method, twelve have synthesized including six rhodanine derivatives ranging from good excellent yield, with four phenylhydrazone two at low yield. The structures all were el...