Background: This study investigated the protective effects of aqueous extracts of Anogeissus leiocarpus (DC) Guill & Perr (Combretaceae) and Terminalia avicennioides Guill & Perr (Combretaceae) root barks, as well as their 1:1 (w/w) mixture on liver redox and haematological parameters of diethylnitrosamine-treated rats. Methods: Rats were orally administered distilled water, diethylnitrosami...

CYP2E1 metabolizes many low-molecular weight toxins and carcinogens. Some in vitro experiments suggest that CYP2E1 may be involved in the metabolic activation of diethylnitrosamine. However, there has been no direct evidence demonstrating a role for CYP2E1 in diethylnitrosamine-mediated carcinogenesis in vivo. To clarify this, we carried out a diethylnitrosamine-induced hepatocarcinogenesis exp...

1. Syrian golden hamsters were treated with a single subcutaneous dose of 200mg of diethylnitrosamine/kg. In the liver the treatment produced a significant and early inhibition of the incorporation of orotic acid into RNA and of leucine into protein. Diethylnitrosamine also lowered basal and 20-methylcholanthrene-stimulated activities of hepatic aryl hydrocarbon hydroxylase. 2. RNA synthesis, p...

Elevated levels of the histidine catabolito formiminoglutamic acid were excreted into the urine of rats that were given both 0.01% diethylnitrosamine in their drinking water for 1 to 5 weeks and an injection of a loading dose of histidine. Similar histidine loading of control rats that received no carcinogen did not produce an elevation in urinary formiminoglutamic acid excretion. The elevation...

A possible synergistic action between the carcinogen diethylnitrosamine injected s.c. and MgO, A12O3, or carbon instilled intratracheally in the respiratory tract of Syrian golden hamsters was studied. Diethylnitrosamine alone induced tumors of the nasal cavity in 50% of the animals. Tumors were also produced in the larynx and trachea but not in the lungs. Groups receiving weekly intratracheal ...

Elevated levels of the histidine catabolito formiminoglutamic acid were excreted into the urine of rats that were given both 0.01% diethylnitrosamine in their drinking water for 1 to 5 weeks and an injection of a loading dose of histidine. Similar histidine loading of control rats that received no carcinogen did not produce an elevation in urinary formiminoglutamic acid excretion. The elevation...

In human hepatocellular carcinoma (HCC) and many other cancers, somatic point mutations are highly prevalent, yet the mechanisms critical in their generation remain poorly understood. S-nitrosoglutathione reductase (GSNOR), a key regulator of protein S-nitrosylation, is frequently deficient in human HCC. Targeted deletion of the GSNOR gene in mice can reduce the activity of the DNA repair prote...


 Purpose: To study the effect of Rhus chinensis Mill. extract (RCME) on diethylnitrosamine (DEN)-induced liver cirrhosis in rats.
 Methods: RCME was obtained by extracting dried water. Liver rat model prepared injecting with DEN once a week for 8 weeks. After 8th-week treatment, biochemical index and oxidative stress were determined DEN-induced Results: Compared group, plasma concent...

background: this study investigated the protective effects of aqueous extracts of anogeissus leiocarpus (dc) guill & perr (combretaceae) and terminalia avicennioides guill & perr (combretaceae) root barks, as well as their 1:1 (w/w) mixture on liver redox and haematological parameters of diethylnitrosamine-treated rats. methods: rats were orally administered distilled water, diethylnitrosamine ...

The gangliosides of human hepatoma biopsies, human hepatoma cell lines, and diethylnitrosamine-induced rat hepatomas were examined. These malignant tissues all expressed increased content of disialolactosylceramide (GD3) with respect to their normal counterparts. During the induction of rat hepatoma by diethylnitrosamine, an increase in GD3 levels appeared as early as 12 wk after initiation of ...