ABSTRACT Depending on the reaction conditions, different aluminium dialkylmalonate derivatives were obtained by reaction of aluminium alkoxides Al(OR)3 (R = Et, iPr, tBu) with dialkylmalonates, viz. Al(malonate)3 (malonate = dimethyl, diethyl, di-iso-propyl and di-tert-butyl malonate), Al2(OiPr)4(malonate)2 (malonate = di-iso-propyl and di-tert-butyl malonate), Al2(OiPr)2(di-iso-propylmalonate)...

The reaction of diethyl malonate with phthaloyl chloride in aceto-nitrile in the presence of tri-ethyl-amine and magnesium chloride results in the formation of the title compound, diethyl 2-(3-oxo-1,3-di-hydro-2-benzo-furan-1-yl-idene)propane-dioate, C15H14O6. One of the ester groups of the diethyl malonate fragment is almost coplanar with the isobenzo-furan unit, while the plane of the other g...

The key intermediate, diethyl 2-acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate (13), for the immunomodulatory agent FTY720 (2: fingolimod) was synthesized via Michael addition of diethyl(acetylamino)malonate (6) to 4-octanoylstyrene (12).

In the title compound, C(26)H(26)O(4), steric crowding of the Ph(3)C- group with the -CH(CO(2)Et)(2) unit leads to a long C-C bond [1.585 (2) Å]. One of the two ethyl groups is disordered over two sites in a 60:40 ratio.

A new guanidine-thiourea organocatalyst has been developed and applied as bifunctional organocatalyst in the Michael addition reaction of diethyl malonate to trans-β-nitrostyrene. Extensive DFT calculations, including solvent effects and dispersion corrections, as well as ab initio calculations provide a plausible description of the reaction mechanism.

the cycloalkylation of diethyl malonate and ethyl cyanoacetate with alkyl dihalide was investigated by using comminuted potassium carbonate as a base and toluene as a solvent in the presence of hexadecyltrimethylammonium bromide (htmab) as a phase-transfer catalyst, which provided a conventional procedure with the advantage of short reaction period and high product yield. the factors influencin...

A novel cyclization reaction of ethenetricarboxylate derivative aromatic compounds in the presence of various Lewis acids gave benzo-annulated cyclic compounds such as oxindole and benzofuran derivatives via Friedel-Crafts intramolecular Michael addition in high yields. For example, the reaction of diethyl 2-[(N-methyl-N-phenylcarbamoyl)methylene]malonate (1a) in the presence of ZnCl2 at room t...

In this study, highly ordered mesoporous silica material (SBA-15) functionalized with Diethyl 2 - (9 -fluorenyl) malonate as a flourophore is reported. The anchoring of flourophores to the hydroxyl group on SBA-15 surface was done with post synthesis method. The obtained materials were characterized by small and wide angle X-ray diffraction, N2 adsorption–desorption, Fourier transform infrared ...