BACKGROUND Toluenediamines are harmful substances. Toluene-2,4-diamine has been assigned to Carcinogen 1B hazard class, pursuant to Regulation (European Community - EC) No. 1272/2008 of the European Parliament and of the Council, and toluene- 2,6-diamine to Mutagen 2 hazard class. The main routes of exposure to toluene-2,4-diamine and toluene-2,6-diamine are via the respiratory tract and the sk...

0020-1693/$ see front matter 2011 Elsevier B.V. A doi:10.1016/j.ica.2011.07.031 ⇑ Corresponding author. Tel.: +39 49 8275172; fax: E-mail address: [email protected] (D. Mo The polymeric [PdCl(dithiocarbamate)]n complexes, in which the ligand ion is dimethyldithiocarbamate (DMDT), pyrrolidine dithiocarbamate (PyDT, (CH2)4NCS2 ) and sarcosine ethyl ester dithiocarbamate (ESDT, EtO2CCH2N(CH...

We have recently presented evidence that diamine oxidase is rcsponsiblc for a portion of the metabolism of histamine in several species (1, 2). This evidence is largely based on the alteration of histamine metabolism produced by compounds which are known to inhibit diamine oxidase in vitro. The inhibitors used were isonicotinylhydrazine (3) and aminoguanidine. The latter is reported to be the m...

Diamine oxidase is continuously released from the intestinal mucosa and carried to the circulation by the lymphatics. The effect of nutrients on this release was examined. Rats were prepared with duodenal and intestinal lymph cannulas. Test mixtures of lipid emulsions containing triolein, oleic acid, or tricaprylin and solutions of carbohydrate and protein were infused into the duodenum. The en...

The synthesis of the new potentially hexadentate ligands N,N'-bis(2,2'-bipyridin-6-ylmethyl)butane-1,4-diamine (bmbu), N,N'-bis(2,2'-bipyridin-6-ylmethyl)pentane-1,5-diamine (bmpt) and N,N'-bis(2,2'-bipyridin-6-ylmethyl)octane-1,8-diamine (bmot) from the condensation of 2,2'-bipyridine-6-carbaldehyde with the appropriate diamine (butane-1,4-diamine, pentane-1,5-diamine and octane-1,8-diamine, r...

Increased plasma histamine levels were associated with significantly lowered diamine and type B monoamine oxidase activities in platelet-rich plasma of atopic eczema (AE) patients. The diamine oxidase has almost normal cofactor levels (pyridoxal phosphate and Cu(2+)) but the cofactor levels for type B monoamine oxidase (flavin adenine dinucleotide and Fe(2+)) are lowered. The biogenic amines pu...

Tetradentate acyclic compartmental Schiff base ligand with N2O2 compartment afford suitable coordination environment for large variety of metal ions. This type ligands can easily be synthesized by [2+1] condensation a carbonyl compounds diamine. Several complexes have been reported from the single- and double-compartment which are products salicylaldehyde, 2-hydroxyacetophenone, 3-methoxysalicy...

A new unsymmetric thioether diamine N - ( 2 - ( 2 - aminophenylthio) ethyl) benzene - 1 , 2 - diamine was prepared through the nucleophilic substitution of cysteaminium chloride with 1 - chloro - 2 - nitrobenzene and then the nitro groups of prepared compuond converted to the amine by zinc powder and ammonium chloride. Then, unsymmetric Schiff bass ligand 2 - ((( 2 - (( 2 - (( 2 - (( 2 - hydrox...

Three classes of diamine linked ferrocene (Fc)-conjugates were prepared and their properties were investigates in solution and the solid state: (a) acyclic diamine-linked 1,n'-Fc conjugates, (b) acyclic diamine-linked 1,n'-Fc peptide conjugates, and (c) cyclic 1,n'-Fc-peptide diamine conjugates. In all cases, the synthetic procedure started from 1,1'-ferrocenecarboxylic acid methyl ester or 1,1...

in plants, γ-aminobutyric acid (gaba) is synthesized by polyamine degradation pathway besides gaba shunt. aminoguanidine (ag) is a specific inhibitor of the key enzyme (diamine oxidase, dao) for gaba formation in polyamine degradation pathway. in this study, ag was applied to study the functions of polyamine degradation pathway on growth and gaba accumulation in germinating fava bean under hypo...