dialysis-related amyloidosis (dra) is characterized by accumulation of amyloid β2-microglobulin (β2m) in the interstitial matrix. matrix substances such as heparin have reportedly been strongly implicated in the pathogenesis of dialysis-related amyloidosis. in clinical setting of hemodialysis, two types of heparin, i.e., high and low molecular heparin (h.m.h. and l.m.h.) have been routinely use...

end-stage failure patients which has been recognized a Amyloid arthropathy decade ago. It generally occurs after several years of The deposition of b2M amyloid clearly is associated renal replacement therapy [1,2]. However, it may be with the syndrome of chronic arthralgias and arthropaseen occasionally in patients with long-standing, severe thy in dialysis patients, although the precise pathog...

To date, there are 27 types of amyloidosis known extracellular fibril proteins in human, and each amyloidosis is characterized amyloid protein precursor, systemic (S) or localized organ (L), and syndrome or involved tissues [1]. In the nomenclature, dialysis-related amyloidosis (DRA) is defined as β2-microglobulin-related (Aβ2M) amyloid which precursor protein is β2microglobulin (β2-m). It is a...

Comment The histological appearance of the amyloid (apple green birefringence under polarised light after staining with Congo red and resistance to pretreatment with potassium permanganate) in each case was consistent with dialysis related amyloidosis and not deposition of AA amyloid. In both patients immunohistology showed strong positivity of the amyloid deposits for P2 microglobulin and weak...