Dendritic cells (DCs) are essential mediators of the host immune response to surrounding microbes. In this study, we investigate the role of DCs in the pathogenesis of a widely used colitis model, dextran sulfate sodium-induced colitis. The effect of dextran sulfate sodium on the production of proinflammatory cytokines and chemokines by bone marrow-derived DCs (BM-DCs) was analyzed. BM-DCs were...

BACKGROUND/AIMS Little is known about the anti-colitis effect of tryptophan or its metabolites. Here, the protective effect and its mechanism of tryptophan administration on dextran sulfate sodium -induced colitis in mice was studied. MATERIALS AND METHODS Twenty C57black6 female mice were equally divided into the control group, and treatment group. The control group received a standard CE-2 ...

The Effect of Different Ozone Concentrations on the Expression β-catenin and HIF-I Genes in Colon Tissue BALB/c Mice Treated with Azoxymethane/dextran Sodium Sulfate

The complement system is a potent effector of innate immunity. To elucidate the pathophysiological role of the complement system in inflammatory bowel disease, we evaluated the effects of anti-C5 antibodies on the development of dextran sulfate sodium-induced colitis in mice. Dextran sulfate sodium-colitis was induced in BALB/c mice with intraperitoneal administrations of anti-C5 antibodies (1 ...

Background Curcumin has been reported to have anti-inflammatory and anti-nociceptive effects. The present study was designed to explore the potential therapeutic effects of curcumin on visceral hyperalgesia and inflammation in a rat model of ulcerative colitis. We observed the effects of orally administered curcumin on the disease activity index, histological change in colon, colorectal distens...

Effect of polyanions on saturation density and production of viscous substance of cells of mouse and hamster cell lines was studied. Cell lines used were 3T6, HA-2 and HA-8 cells. Polyanions were dextran sulfate, (3,6-anhydro-4-o-beta-galactopyranosyl-2-D-galactopyranose-2,4'-bis (potassium/sodium sulfate) (1 leads to 3) polysaccharide (polygeenan) and dextran phosphate. Dextran sulfate reduced...

Objective(s):Inflammatory bowel disease (IBD) results from dysregulation of intestinal mucosal immunity. It is an incurable disease that affects millions of people worldwide. Developing new strategies for the treatment of colitis has been a major challenge. Here, we report the effect of calycosin, a plant-derived flavonoid, in successfully managing colitis in murine model. Material and Methods:...

Dysfunction of gut immune regulation is involved in mucosal damage in inflammatory bowel disease (IBD). However, there is still no efficacious immune-regulator for the treatment of IBD. Alloferon is a novel immune-modulatory peptide that was originally isolated from infected insects. It shows anti-inflammatory effects by the regulation of cytokine production by immune cells and their activities...

Interactions of fibrinogen with dextran sulfate, dextran, and carboxymethyl cellulose were investigated by turbidity measurement, chemical analysis, and electrophoresis. Dextran sulfate and fibrinogen combined even in the physiological pH region where both of them have negative net charges, and formed a precipitate and soluble complex. Since no complex formation was observed in the case of dext...