BACKGROUND Recently, applications of albumin nanoparticles as drug delivery carriers have increased. Most toxicology studies have shown that surface chemistry and size of nanoparticles play an important role in biocompatibility and toxicity. OBJECTIVE The effect of desolvating agents with different chemical properties on the size of synthesized HSA NPs was investigated. MATERIALS AND METHOD...

Background: Recently, applications of albumin nanoparticles as drug delivery carriers have increased. Most toxicology studies have shown that surface chemistry and size of nanoparticles play an important role in biocompatibility and toxicity. Objective: The effect of desolvating agents with different chemical properties on the size of synthesized HSA NPs was investigated. Materials and Method...

The objective of the present work is to prepare Mefenamic acid loaded bovine serum albumin nanoparticles by Desolvation technique. Drug-polymer dispersion was prepared under continuous mechanical stirring. Desolvating agent was added by means of two methods. In continuous addition method desolvating agent was added at the rate of 1ml/1min whereas in Intermittent addition method the desolvating ...

For size analysis of small nanoparticles (i.e., smaller than 10 nm) using spICP-MS, two approaches were employed to improve the signal-to-noise ratio ion signals emanating from nanoparticles. The first one was enhancement instrumental sensitivity a desolvating system. second approach separation background through deconvolution method. A combination these enabled us measure 5 nm gold nanoparticl...

The desolvating droplets of EESI were used as microreactor for the mass spectrometric study of short-lived transients of reactions in condensed liquid phase in the millisecond time region. The electron-transfer-catalyzed dimerization of trans-anethole was investigated and the intermediates in the radical cation chain reaction were isolated and characterized by MS-MS. The distonic tetramethylene...

BACKGROUND Currently, the discovery of effective chemotherapeutic agents poses a major challenge to the field of cancer biology. The present study focuses on enhancing the therapeutic and anti cancer properties of atorvastatin calcium loaded BSA (ATV-BSA) nanoparticles in vitro. METHODOLOGY/RESULTS BSA-ATV nanoparticles were prepared using desolvation technique. The process parameters were op...

The prevalence of salt bridges across protein binding interfaces is surprising given the significant costs of desolvating the two charged groups upon binding. These desolvation costs, which are difficult to examine using laboratory experiments, have been computed in previous studies using the Poisson-Boltzmann (PB) implicit solvent model. Here, for the first time, we directly compare the PB imp...

A MC-ICP-MS technique for precise isotope analysis of sub-nanogram sized Pb sample was developed. We found that combined uses real-time on-line Tl doping, Tl-isotope-based mass discrimination correction, and desolvating nebulizer operated at relatively low temperature give the best analytical results. The 2SD reproducibility analyses with 0.4 ng better than ±0.0032 206Pb/204Pb 207Pb/204Pb, ±0.0...