background & objective: lichen planus is a mucocutaneous disease which is relatively common and in 30-70% of patients, mucosal lesions can be seen and known as a precancerous lesion but its etiology is not completely understood. desmogleins i and iii are the main desmosomal transmembrane proteins. these proteins have been identified as the autoantigen of the autoimmune disease. the aim of t...

Background & Objective: Lichen planus is a mucocutaneous disease which is relatively common and in 30-70% of patients, mucosal lesions can be seen and known as a precancerous lesion but its etiology is not completely understood. Desmogleins I and III are the main desmosomal transmembrane proteins. These proteins have been identified as the autoantigen of the autoimmune disease. The aim...

BACKGROUND & OBJECTIVE Lichen planus is a mucocutaneous disease which is relatively common and in 30-70% of patients, mucosal lesions can be seen and known as a precancerous lesion but its etiology is not completely understood. Desmogleins I and III are the main desmosomal transmembrane proteins. These proteins have been identified as the autoantigen of the autoimmune disease. The aim of this s...

For the extracellular (EC) domain of E-cadherin to function in homophilic adhesion it is thought that its intracytoplasmic (IC) domain must bind alpha- and beta-catenins, which link it to the actin cytoskeleton. However, the IC domain of pemphigus vulgaris antigen (PVA or Dsg3), which is in the desmoglein subfamily of the cadherin gene superfamily, does not bind alpha- or beta-catenins. Because...

Much of the original research on desmosomes and their biochemical components was through analysis of skin and mucous membranes. The identification of desmogleins 1 and 3, desmosomal adhesion glycoproteins, as targets in pemphigus, a fatal autoimmune blistering disease of the skin and mucous membranes, provided the first link between desmosomes, desmogleins, and human diseases. The clinical and ...

Desmogleins are glycoproteins of the desmosomes squamous epithelia. To understand roles desmogleins (Dsgs) 1 and 3 in cancer, tissue microarrays containing 16,100 samples from 138 different tumour types were analysed by IHC. Dsg1 Dsg3 staining was detectable 39 (28%) 49 (36%) categories. Four 12 cell cancer showed ≥90% positivity for and/or Dsg3, another 7 SQCC 80–89% positivity. also found bas...

Autoimmune bullous disease is sometimes seen in patients with rheumatoid arthritis (RA). In addition, pemphigus can be induced by certain disease modifying anti-rheumatic drugs (DMARDs) for RA, such as thiol compounds. Antibodies against desmogleins are occasionally detected in the sera of drug-induced pemphigus patients. We herein describe a case which showed ulceration following herpes zoster...