نتایج جستجو برای: Dermcidin

تعداد نتایج: 87  

2012
Rajeshwary Ghosh Uttam K. Maji Rabindra Bhattacharya Asru K. Sinha

Hypertension and diabetes mellitus are considered to be two major atherosclerotic risk factors for coronary artery disease (CAD). A stress-induced protein identified to be dermcidin isoform 2 of Mr. 11 kDa from blood plasma of hypertensive persons when injected (0.1 μM) in rabbits increased the systolic pressure by 77% and diastolic pressure by 45% over the controls within 2 h. Ingestion of ace...

2014
Rajeshwary Ghosh Sarbashri Bank Rabindra Bhattacharya Nighat N Khan A Kumar Sinha

The effect of dermcidin isoform 2 (dermcidin), an environmentally induced stress protein, was investigated on the genesis of diabetes mellitus and hypertension, the two major atherosclerotic risk factors. The role of dermcidin as an atherosclerotic risk factor related to the impaired systemic insulin level was investigated. Dermcidin was prepared by electrophoresis using plasma from the subject...

Journal: :Antimicrobial agents and chemotherapy 2009
Min Li Kevin Rigby Yuping Lai Vinod Nair Andreas Peschel Birgit Schittek Michael Otto

Antimicrobial peptides (AMPs) form an important part of the innate host defense. In contrast to most AMPs, human dermcidin has an anionic net charge. To investigate whether bacteria have developed specific mechanisms of resistance to dermcidin, we screened for mutants of the leading human pathogen, Staphylococcus aureus, with altered resistance to dermcidin. To that end, we constructed a plasmi...

Journal: :Journal of innate immunity 2012
Birgit Schittek

Eccrine sweat glands, which are distributed over the whole bodies of primates and humans, have long been regarded mainly to have a function in thermoregulation. However, the discovery of dermcidin-derived antimicrobial peptides in eccrine sweat demonstrated that sweat actively participates in the constitutive innate immune defense of human skin against infection. In the meantime, a number of st...

2012
Rajeshwary Ghosh Rabindra Bhattacharya Gorachand Bhattacharya Asru K. Sinha

The role of stress induced development of Type-1 diabetes mellitus (T1DM) as opposed to autoimmunity remains obscure. It has been reported that a stress induced protein, identified to be dermcidin isoform 2 (dermcidin) inhibited insulin synthesis in both the pancreatic β cells and the hepatic cells. As dermcidin effect could be neutralized by the increased production of systemic nitric oxide (N...

2014
Sarbashri Bank Pradipta Jana Smarajit Maiti Santanu Guha A. K. Sinha

The aggregation of platelets on the plaque rupture site on the coronary artery is reported to cause both acute coronary syndromes (ACS) and acute myocardial infarction (AMI). While the inhibition of platelet aggregation by acetyl salicylic acid was reported to produce beneficial effects in ACS, it failed to do in AMI. The concentration of a stress induced protein (dermcidin isoform-2) was much ...

Journal: :International journal of oncology 2011
Alastair G Lowrie Paul Dickinson Nicholas Wheelhouse Grant D Stewart Alan J Ross Thorsten Forster James A Ross

Dermcidin is a candidate oncogene capable of increasing the number of cultured neuronal, breast cancer and prostate cancer cells and improving the survival of hepatic cells. The dermcidin gene encodes the proteolysis-inducing factor core peptide (PIF-CP) and the skin antimicrobial peptide DCD-1. The peptide responsible for inducing proliferation of cells and the mechanisms involved are unknown....

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Lynnie Trzoss Takashi Fukuda Letícia V Costa-Lotufo Paula Jimenez James J La Clair William Fenical

Natural products continue to provide vital treatment options for cancer. Although their translation into chemotherapeutics is complex, collaborative programs continue to deliver productive pipelines for cancer chemotherapy. A new natural product, seriniquinone, isolated from a marine bacterium of the genus Serinicoccus, demonstrated potent activity over a select set of tumor cell lines with par...

2016
Idoia Ortega‐Martínez Jesús Gardeazabal Asier Erramuzpe Ana Sanchez‐Diez Jesús Cortés María D. García‐Vázquez Gorka Pérez‐Yarza Rosa Izu Jose Luís Díaz‐Ramón Ildefonso M. de la Fuente Aintzane Asumendi María D. Boyano

Like many cancers, an early diagnosis of melanoma is fundamental to ensure a good prognosis, although an important proportion of stage I-II patients may still develop metastasis during follow-up. The aim of this work was to discover serum biomarkers in patients diagnosed with primary melanoma that identify those at a high risk of developing metastasis during the follow-up period. Proteomic and ...

Background:Brucella spp. are facultative intracellular pathogens that can cause chronic infections in many tissues and organs. Objectives: To investigate serum dermcidin, salusin-alpha, salusin-beta and TNF-alpha levels and their correlation with each other in patients with acute brucellosis. Methods: From 50 patients hospitalized upon...

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