نتایج جستجو برای: Delphinidin

تعداد نتایج: 427  

Journal: :Carcinogenesis 2009
Jung Yeon Kwon Ki Won Lee Jong-Eun Kim Sung Keun Jung Nam Joo Kang Mun Kyung Hwang Yong-Seok Heo Ann M Bode Zigang Dong Hyong Joo Lee

Cyclooxygenase-2 (COX-2), a key mediator of inflammation, and its product, prostaglandin E(2) (PGE(2)), enhance carcinogenesis, particularly in skin. Ultraviolet (UV) B is the most carcinogenic component of solar irradiation, and a crucial role of COX-2 in UVB-mediated skin carcinogenesis has been reported. Here, we investigated the effects of delphinidin, an abundant dietary anthocyanin, on UV...

2016
Dae Cheol Nam Young Sool Hah Jung Been Nam Ra Jeong Kim Hyung Bin Park

Age-related rotator cuff tendon degeneration is related to tenofibroblast apoptosis. Anthocyanins reduce oxidative stress-induced apoptotic cell death in tenofibroblasts. The current study investigated the presence of cell protective effects in cyanidin and delphinidin, the most common aglycon forms of anthocyanins. We determined whether these anthocyanidins have antiapoptotic and antinecrotic ...

2014
Chang Hoon Bae Bo Sung Jeon Yoon Seok Choi Si-Youn Song Yong-Dae Kim

OBJECTIVES Delphinidin is one of the anthocyanidins. It is believed to have anti-inflammatory property including antioxidant, antiangiogenic, and anti-cancer properties. However, the anti-inflammatory effect of delphinidin in mucin-producing human airway epithelial cells has not been determined. Therefore, this study was conducted in order to investigate the effect and the brief signaling pathw...

2011
Tuba Ozbay Rita Nahta

Delphinidin is a polyphenolic compound found in many brightly colored fruits and vegetables. Delphinidin is also the major bioactive component found in many dietary supplements that are currently consumed as complementary cancer medicine including pomegranate extract. The purpose of the current study was to determine the in vitro biological effects of delphinidin on established breast cancer ce...

Journal: :Oncology reports 2015
Bo Yuan Saki Okusumi Yuta Yoshino Chihiro Moriyama Sachiko Tanaka Toshihiko Hirano Norio Takagi Hiroo Toyoda

The effects of delphinidin were investigated by focusing on growth inhibition, cell cycle arrest and apoptosis induction in the human acute promyelocytic leukemia (APL) NB4 cell line. Delphinidin exhibited a dose- and time-dependent cytotoxic effect against NB4 cells. Almost no cell cycle arrest, but an apparent increase in the percentage of sub-G1 cells was observed in delphinidin-treated cell...

Journal: :Chemico-biological interactions 2010
Chun-Ye Chen Long Yi Xin Jin Man-Tian Mi Ting Zhang Wen-Hua Ling Bin Yu

Moderate consumption of natural dietary polyphenolic compounds can reduce the risk of cardiovascular diseases. Here we investigated the protective effects of delphinidin against oxidized low-density lipoprotein (oxLDL)-induced damage in human umbilical vein endothelial cells (HUVECs). The MTT assay showed that 2h pre-incubation with delphinidin markedly restored the oxLDL-induced viability loss...

Journal: :PloS one 2015
Thérèse Keravis Laure Favot Abdurrazag A Abusnina Anita Anton Hélène Justiniano Raffaella Soleti Eid Alabed Alibrahim Gilles Simard Ramaroson Andriantsitohaina Claire Lugnier

The vasculoprotective properties of delphinidin are driven mainly by its action on endothelial cells. Moreover, delphinidin displays anti-angiogenic properties in both in vitro and in vivo angiogenesis models and thereby might prevent the development of tumors associated with excessive vascularization. This study was aimed to test the effect of delphinidin on melanoma-induced tumor growth with ...

2016
Wooje Lee Jung-Mi Yun

Delphinidin possesses strong anti-oxidant, anti-inflammatory, and anti-cancer properties. Suppression of the Wnt/β-catenin signaling pathway is a potential strategy for chemoprevention and therapy. As aberrant activation of the β-catenin signaling pathway contributes to prostate cancer progression, we evaluated the effect of delphinidin on this pathway in human PC3 prostate cancer cells. An MTT...

2016
Mi-Hyeon Jeong Hyeonseok Ko Hyelin Jeon Gi-Jun Sung Soo-Yeon Park Woo Jin Jun Yoo-Hyun Lee Jeongmin Lee Sang-wook Lee Ho-Geun Yoon Kyung-Chul Choi

Delphinidin is a major anthocyanidin compound found in various fruits. It has anti-inflammatory, anti-oxidant, and various other biological activities. In this study, we identified the epigenetic modulators that mediate the apoptotic effect of delphinidin in human prostate cancer cells. We found that treatment of LNCaP cells (a p53 wild-type, human prostate cancer cell line) with delphinidin in...

2017
Whasun Lim Gwonhwa Song

Delphinidin is a member of the anthocyanidin family and is a natural pigment in red cabbage, berries, sweet potatoes and grapes. It possesses nutraceutical properties against various chronic diseases and types of cancer. However, little is known about its preventative effects on epithelial ovarian cancer, a disease that is associated with a low survival rate, a poor prognosis and a high rate of...

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