Elevated concentrations of peptide hormones have been described previously in human breast fluid. In the current study, the levels of cortisol, progesterone, testosterone, dihydrotestosterone, androsterone, androsterone sulfate, dehydroisoandrosterone, dehydroisoandrosterone sulfate, estradiol, estrone, estradiol sulfate, and estrone sulfate were measured. The levels of the four 17-ketosteroids...

The available evidence suggests that most of the steriod hormone endproducts which are eliminated from the body by way of the urine are conjugated with an inorganic or organic acid. This conjugation presumably facilitates their transportation and excretion by rendering them soluble in water or urine. Examples of such conjugated steroids which have been isolated from urine as sulfates are andros...

The 24-hr mean plasma concentrations of dehydroisoandrosterone (DHA) and dehydroisoandrosterone sulfate were measured in 11 women with primary operable breast cancer, ages 31 to 78 years, and in 37 normal women, ages 21 to 75 years. In contrast to the marked and progressive decline of DHA and dehydroisoandrosterone sulfate concentration with age in the normal women, the concentrations of both s...

The conversion of dehydroisoandrosterone to its ,B-D-glucopyranoside is readily effected by surviving slices of the potato tuber at pH 8. This reaction is largely limited to dehydroisoandrosterone and isoandrosterone, and is slowly reversed at pH 4 as the result of weak P-glucosidase-like activity. Potatoes also contain an active /?-glucuronidase which differs from known preparations in possess...

N-Bromosuccinimide, Zl5-Steroids, Diosgenin, Cholesterol, Stigmastane, Dehydroisoandrosterone The reaction of N-bromosuccinimide with Zl5-steroids such as, diosgenin, cholesterol, stigmasterol and dehydroisoandrosterone were studied. It was found that NBS in a solvent mixture of acetone, water and acetic acid (8:1:0.1) oxidises the olefinic bond of all the previous steroidal compounds to the co...

Methods for the quantitative determination of steroids have been developed, based on their specific chemical or physicochemical properties. The Zimmermann reaction (1) and the Kober reaction (2) have been found useful in the quantitative determination of certain individual steroids occurring in urine. Modifications of these reactions have been reported by Callow et al. (3), Holtorff and Koch (4...

Methods for the quantitative determination of steroids have been developed, based on their specific chemical or physicochemical properties. The Zimmermann reaction (1) and the Kober reaction (2) have been found useful in the quantitative determination of certain individual steroids occurring in urine. Modifications of these reactions have been reported by Callow et al. (3), Holtorff and Koch (4...

Dehydroisoandrosterone, administered orally to New Zealand Black/New Zealand White F1 hybrid mice, prevented the formation of antibodies to double-stranded DNA and prolonged survival in this murine model of lupus erythematosus.

The incubation of pregnenolone or dehydroisoandrosterone with bovine or rat adrenal homogenates leads to the formation of nonpolar metabolites of these steroids. The enzymatically prepared compounds have properties that are similar to the endogenous lipoidal derivatives of pregnenolone found in bovine adrenals (Hochberg, R. B., Bandy, L., Ponticorvo, L., and Lieberman, S. (1977) Proc. Natl. Aca...