Abstract The acene series, an important class of linearly polycyclic aromatic hydrocarbons, are interest owing to their unique physicochemical features. With increase in the number fused benzene rings, acenes display evolution electronic structure and properties. Thus, efforts have been devoted synthesis longer acenes, with dodecacene being longest (12 rings) reported date. However, formation p...

Molybdenum carbides have been believed to catalyze C–C coupling generate aromatics from methane conversion. Herein, a systematic study of activation on the Mo-terminated Mo2C surfaces performed using density functional theory calculations. Our results indicate that ?-Mo2C surface exhibits superior activity toward activation. Carburization through insertion carbon atoms into subsurface interstit...

Introduction: Pregnancy increases the clearance of CYP3A4 substrate drugs and pregnancy-related hormones (PRHs) induce hepatic expression metabolism. However, it remains unclear to what extent magnitude PRH-evoked changes in CYP3A metabolism varies across multiple substrates. This study quantified impact PRHs on protein concentrations buprenorphine human hepatocytes, compared these effects nife...

BACKGROUND Thromboxane (TX) A2 is a pro-thrombotic prostanoid synthesized by activated platelets, biotransformed into 11-dehydro-TXB2, measurable in urines. Eleven-dehydro-TXB2 excretion is increased in high risk cardiovascular diseases; however, this cardiovascular biomarker awaits validation in large trials. The need of large urine volume (8 - 10 mL) and the unknown stability of 11-dehydro-TX...

To study the effect of calcium ion on aromatization of an androgenic precursor to estradiol by the placenta, cultured term trophoblasts were used as a model system. Secretion of estradiol into the culture medium was regarded as indicating aromatization, since cells cultured with no androgenic precursors produced only insignificant amounts of estradiol. EGTA, verapamil and ionophore A23187 inhib...

The aromatization of androstenedione is inhibited in the presence of aminoglutethimide, diethylaminoethyl-2,2-diphenyl valerate HCl (SKF 525-A), and 1W3 M KCN, but not carbon monoxide or metyrapone. The role of cytochrome P-450 in this reaction could not, therefore, be unequivocally established by inhibition studies. However, it was determined that steroid binding to placental microsomal cytoch...

BACKGROUND Urinary 11-dehydro-thromboxane (TX)B2 has been described as a potential predictive biomarker of major adverse cardiovascular events (MACEs) in high cardiac risk patients. This part of LTIMI (Leukotrienes and Thromboxane In Myocardial Infarction) study aimed to evaluate the relationship between 11-dehydro-TXB2 and MACEs in patients with acute myocardial infarction (AMI). METHODS AND...