We present the first documented case of metastatic melanoma to orbit with dedifferentiation. A patient a history lip and other poorly differentiated carcinomas presented both sub-brow an intraorbital mass. Radiographically intraoperatively, mass communicated via perineural spread along supraorbital nerve. Histopathology confirmed diagnosis based on melanocytic markers, SOX-10 Melan-A; dediffere...

Dedifferentiated liposarcoma (DDL) with divergent dedifferentiation is uncommonly reported variable incidences. Liposarcomas, particularly those manifesting dedifferentiation, occur in the retroperitoneum. They grow into large size, present at very late stages, and can have a poor clinical outcome. Here we rare case of recurrent dedifferentiated dual heterologous differentiation osteosarcoma Ch...

Dedifferentiation, or decreased processing specificity, has been suggested to represent a ubiquitous characteristic of cognitive aging. In this study, we examined both age-related differences and intra-group differences in neural specificity in the ventral visual cortex for color, words, faces and places. Our results demonstrated that neural dedifferentiation was not ubiquitous across stimulus ...

background dedifferentiation of chondrocytes remains a major problem for cartilage tissue engineering. chondrocytes loss differentiated phenotype in in vitro culture that is undesired for repair strategies. the chondrocyte is surrounded by a pericellular matrix (pcm), together forming the chondron. pcm has a positive effect on the maintenance of chondrocyte phenotype during culture in compariso...

After nerve injury, Schwann cells proliferate and revert to a phenotype that supports nerve regeneration. This phenotype-changing process can be viewed as Schwann cell dedifferentiation. Here, we investigated the role of extracellular ATP in Schwann cell dedifferentiation and proliferation during Wallerian degeneration. Using several markers of Schwann cell dedifferentiation and proliferation i...

PURPOSE The adult newt can regenerate lens from pigmented epithelial cells (PECs) of the dorsal iris via dedifferentiation. The purpose of this research is to obtain sequence resources for a newt lens regeneration study and to obtain insights of dedifferentiation at the molecular level. METHODS mRNA was purified from iris during dedifferentiation and its cDNA library was constructed. From the...

Background: Peripheral nerve injury (PNI) is a common condition that compromises motor and sensory functions. Peripheral nerves are known to have regenerative capability and the pineal hormone, melatonin, is known to aid nerve regeneration. However, the role of Schwann cells and the pathways involved remain unclear. Thus, the aim of this study is to identify the effects of melatonin on Schwann ...