debottlenecking of heat exchanger networks is a very important issue, when a plant is subject to process changes and/or increased throughput. in previous paper, a new targetting method was introduced, that allowed the designer to consider hydrodynamic constraints when debottlenecking a network. in this paper, a design procedure, which guarantees the consistency of the results of targetting stag...

retrofit of heat exchanger networks for energy saving and/or debottlenecking is one of important aspects of process engineering. pinch technology, as the most efficient tool for the analysis of these networks, has been applied to hundreds of such projects and shown satisfactory results. however, all the existing methods for debottlenecking, using pinch technology, are either based on assumed he...

for energy saving retrofit projects, its economics are usually evaluated in terms of capital investment and payback time. the capital investment is in direct relation to the total heat recovery area of the network and the payback time factor is base on both the area and the energy savings. the debottlenecking is an increased throughput, which can be profitable in economic sense. the combination...

2015 The commercial potential of monoclonal antibodies (mAbs) has been continuously increasing during the last years alongside with the number of approved mAb-based drugs and clinical trials. Despite their effectiveness and safety, the general access to this class of biopharmaceuticals is barred by high selling prices. Downstream processing is now considered the bottleneck in the manufacturing ...