نتایج جستجو برای: DVL

تعداد نتایج: 396  

Journal: :Human molecular genetics 1996
A Pizzuti F Amati G Calabrese A Mari A Colosimo V Silani L Giardino A Ratti D Penso L Calzà G Palka G Scarlato G Novelli B Dallapiccola

The Drosophila dishevelled gene (dsh) encodes a secreted glycoprotein, which regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. We have isolated and characterized cDNA clones from two different human dsh-homologous genes, designated as DVL-1 and DVL-3. DVL-1 and DVL-3 putative protein products show 64% ...

2003
Feng Cong Liang Schweizer Harold Varmus

Wnt signaling is critical to many aspects of development, and aberrant activation of the Wnt signaling pathway can cause cancer. Dishevelled (Dvl) protein plays a central role in this pathway by transducing the signal from the Wnt receptor complex to the -catenin destruction complex. Dvl also plays a pivotal role in the planar cell polarity pathway that involves the c-Jun N-terminal kinase (JNK...

Journal: :The Journal of biological chemistry 2011
Yi-Tong Liu Qiong-Jie Dan Jiawei Wang Yingang Feng Lei Chen Juan Liang Qinxi Li Sheng-Cai Lin Zhi-Xin Wang Jia-Wei Wu

The Wnt signaling plays pivotal roles in embryogenesis and cancer, and the three DIX domain-containing proteins, Dvl, Axin, and Ccd1, play distinct roles in the initiation and regulation of canonical Wnt signaling. Overexpressed Dvl has a tendency to form large polymers in a cytoplasmic punctate pattern, whereas the biologically active Dvl in fact forms low molecular weight oligomers. The molec...

2018
Visal Moolasart Suthat Chottanapund Jarurnsook Ausavapipit Sirirat Likanonsakul Sumonmal Uttayamakul Don Changsom Hatairat Lerdsamran Pilaipan Puthavathana

The RNA viral load of human immunodeficiency virus (HIV) is initially used to determine the status of the HIV infection. The goal of therapy following treatment failure is to achieve and maintain virologic suppression. A detectable viral load may relate to the progression of HIV infection. A cross-sectional survey was conducted from January 2013 to December 2014 at the Bamrasnaradura Infectious...

2010
Takuji Tsuji Yusaku Ohta Yuya Kanno Kenzo Hirose Kazumasa Ohashi Kensaku Mizuno

The Wnt-induced planar cell polarity (PCP) signaling pathway is essential for polarized cell migration and morphogenesis. Dishevelled (Dvl) and its binding protein Daam1 mediate RhoA activation in this pathway. WGEF, a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family, was shown to play a role in Wnt-induced RhoA activation in Xenopus embryos. However, it has remained unknow...

2000
Olga Krylova Marcus J. Messenger Patricia C. Salinas

Dishevelled has been implicated in the regulation of cell fate decisions, cell polarity, and neuronal function. However, the mechanism of Dishevelled action remains poorly understood. Here we examine the cellular localization and function of the mouse Dishevelled protein, DVL-1. Endogenous DVL-1 colocalizes with axonal microtubules and sediments with brain microtubules. Expression of DVL-1 prot...

ژورنال: :دانشور پزشکی 0
دکتر سیدسعید سیدمرتاض seyed saeed seyed mortaz دکتر فرزانه گلفام farzaneh golfam دکتر علیرضا خلج alireza khalaj دکتر حمیدرضا طاهری hamidreza taheri ناهید خلدی nahid kholdi

مقدمه: شایع ترین روش دستیابی عروقی برای دیالیز خونی ( hemodialysis ) فیستول شریانی وریدی است. روش های متعددی برای ایجاد فیستول وجود دارد. تاکنون به منظور دستیبابی به فیستولی با بقای بالاتر و عوارض کم تر، تکنیک های مختلفی ارائه شده است. این مطالعه به بررسی مقایسه ای روشی که در آن ورید دیستال فیستول پهلو به پهلو بسته می شود ( distal vein ligation) (dvl ) با روش آناستوموز بدون لیگاتور شاخه دیستال ...

Journal: :The Journal of Cell Biology 2000
Olga Krylova Marcus J. Messenger Patricia C. Salinas

Dishevelled has been implicated in the regulation of cell fate decisions, cell polarity, and neuronal function. However, the mechanism of Dishevelled action remains poorly understood. Here we examine the cellular localization and function of the mouse Dishevelled protein, DVL-1. Endogenous DVL-1 colocalizes with axonal microtubules and sediments with brain microtubules. Expression of DVL-1 prot...

2017
Marc Gentzel Alexandra Schambony

Dishevelled (DVL) proteins are highly conserved in the animal kingdom and are important key players in β-Catenin-dependent and -independent Wnt signaling pathways. Vertebrate genomes typically comprise three DVL genes, DVL1, DVL2, and DVL3. Expression patterns and developmental functions of the three vertebrate DVL proteins however, are only partially redundant in any given species. Moreover, e...

Journal: :Hypertension 2010
Pratima Malekar Marco Hagenmueller Adamma Anyanwu Sebastian Buss Marcus R Streit Celine S Weiss David Wolf Johannes Riffel Alexander Bauer Hugo A Katus Stefan E Hardt

The evolutionary conserved Wnt signaling pathway regulates cardiogenesis. However, members of the Wnt pathway are also expressed in the adult heart. Although Wnt-signaling is quiescent under normal conditions, we noticed activation on pathological stress of the heart, such as chronic afterload increase. To examine the role of Wnt signaling on the postnatal heart, we modified the expression and ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید