background attention deficit hyperactivity disorder (adhd) is a multi-factorial disorder that has defined by hyperactivity, impulsivity and attention deficits. various neurotransmitters such as dopamine can play a role in its pathophysiology. the aim of this study was to examine the association of two common single nucleotide polymorphisms in drd2 gene, taq i a (t/c) and taq i b (g/a), with adh...

backgroundattention deficit hyperactivity disorder (adhd), is a multifactorial disorder and converging evidence has implicated abnormalities of dopamine neurotransmission. the aim of this study was to examine the association of -141 polymorphisms in drd2 gene with adha among iranian-azeri population.materials and methods a case–control association study included 153 patients with attention defi...

The D2 dopamine receptor (DRD2) has been one of the most extensively investigated gene in neuropsychiatric disorders. After the first association of the TaqI A DRD2 minor (A1) allele with severe alcoholism in 1990, a large number of international studies have followed. A meta-analysis of these studies of Caucasians showed a significantly higher DRD2 A1 allelic frequency and prevalence in alcoho...

Findings on the association between the risk for developing bipolar disorder and the functions of the serotonin transporter-linked polymorphic region gene (5-HTTLPR) and dopamine D2 receptor gene (DRD2) variants are contradictory. One explanation for this is that a gender difference may exist for genetic contributions. We compared the gender-related main effects and the gene-to-gene interaction...

Despite reported findings, explanations for within-species variation in behavioural performance on cognitive tests are still understudied. Cognitive processes influenced by environmental and genetic differences, where stimulation monoaminergic systems predicted to be important. To explore individual impulsivity (a behaviour that is negatively correlated with inhibitory control), we experimental...

Abstract Exposure to the hight-fat diet may alter control of food intake promoting hyperphagia and obesity. The objective this study was investigate effects on dopamine receptors (drd1 drd2), proopiomelanocortin (pomc), neuropeptideY (npy) genes expression, preference in adult rats. Wistar female rats were fed a or during pregnancy lactation. offspring allocated into groups: Lactation – Control...

Several lines of evidence suggest that genes involved in dopamine (DA) transmission may contribute to creativity. Among these genes, the catechol-O-methyltransferase gene (COMT) and the dopamine D2 receptor gene (DRD2) are the most promising candidates. Our previous study has revealed evidence for the involvement of DRD2 in creative potential. The present study extended our previous study by sy...

The aim of this study was to analyse the relationships between polymorphisms in four candidate genes (AR, DAT1, DRD2, and COMT) and aggression in men from a traditional society of East African pastoralists, the Datoga. Buss and Perry's Aggression Questionnaire was used to measure aggression. The number of CAG repeats in the AR gene was negatively correlated with physical aggression, anger, and ...

Introduction: Hyperprolactinemia is a common serious side effect of antipsychotic medications that are currently used in the treatment of patients with schizophrenia. Pharmacogenetic approaches offer the possibility of identifying patient-specific biomarkers for predicting the risk of this side effect. We investigated a possible relationship between variants (SNPs) in genes for cytochrome 2D6 (...