نتایج جستجو برای: DPV Sesnor

تعداد نتایج: 672  

2014
Ayman Akil Brid Devlin Marilyn Cost Lisa Cencia Rohan

The HIV-1 replication inhibitor dapivirine (DPV) is one of the most promising drug candidates being used in topical microbicide products for prevention of HIV-1 sexual transmission. To be able to block HIV-1 replication, DPV must have access to the viral reverse transcriptase enzyme. The window for DPV to access the enzyme happens during the HIV-1 cellular infection cycle. Thus, in order for DP...

2017
Yuanyuan Zhang Lili Zhao Yan Zhou Chenxi Diao Lingxia Han Niu Yinjie Shengwang Liu Hongyan Chen

The immune-releasing effects of L-glutamine (Gln) supplementation in duck plague virus (DPV)-infected ducklings were evaluated in 120 seven-day-old ducklings that were divided into 8 groups. The ducklings in control and DPV, 0.5Gln and DPV + 0.5Gln, 1.0Gln and DPV + 1.0Gln, and 2.0Gln and DPV + 2.0Gln received 0, 0.5, 1.0, and 2.0 g of Gln/kg feed/d by gastric perfusion, respectively. Then, the...

Journal: :The Journal of pharmacology and experimental therapeutics 2013
Tomotaka Shingaki Tadayuki Takashima Ryosuke Ijuin Xuan Zhang Tomohiro Onoue Yumiko Katayama Takashi Okauchi Emi Hayashinaka Yilong Cui Yasuhiro Wada Masaaki Suzuki Kazuya Maeda Hiroyuki Kusuhara Yuichi Sugiyama Yasuyoshi Watanabe

We developed a pravastatin derivative, sodium (3R,5R)-3,5-dihydroxy-7-((1S,2S,6S,8S)-6-hydroxy-2-methyl-8-((1-[(11)C]-(E)-2-methyl-but-2-enoyl)oxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoate ([(11)C]DPV), as a positron emission tomography (PET) probe for noninvasive measurement of hepatobiliary transport, and conducted pharmacokinetic analysis in rats as a feasibility study for future cli...

2013
Tomotaka Shingaki Tadayuki Takashima Ryosuke Ijuin Xuan Zhang Tomohiro Onoue Yumiko Katayama Takashi Okauchi Emi Hayashinaka Yilong Cui Yasuhiro Wada Masaaki Suzuki Kazuya Maeda Hiroyuki Kusuhara Yuichi Sugiyama Yasuyoshi Watanabe

We developed a pravastatin derivative, sodium (3R,5R)-3,5dihydroxy-7-((1S,2S,6S,8S)-6-hydroxy-2-methyl-8-((1-[C]-(E)2-methyl-but-2-enoyl)oxy)-1,2,6,7,8,8a-hexahydronaphthalen-1yl)heptanoate ([C]DPV), as a positron emission tomography (PET) probe for noninvasive measurement of hepatobiliary transport, and conducted pharmacokinetic analysis in rats as a feasibility study for future clinical study...

Journal: :Intervirology 2010
Ming-Sheng Cai An-Chun Cheng Ming-Shu Wang Wan-Ping Chen Xian Zhang Shang-Xi Zheng Yang Pu Kun-Peng Lou Yao Zhang Lei Sun Lu-Lu Wang De-Kang Zhu Qi-Hui Luo Xiao-Yue Chen

OBJECTIVE Previous study has demonstrated that the duck plague virus (DPV) UL35 gene can be expressed as a recombinant fusion protein, and the prepared antiserum has a high reactivity and specificity against the purified recombinant protein. In the present study, to elucidate the properties and functions of its encoding protein, the UL35 gene product (VP26) was identified by using the prepared ...

Journal: :Genetics and molecular research : GMR 2014
K F Sun A C Cheng M S Wang

Glycoprotein C is one of the duck plague virus (DPV) glycoproteins and is encoded by the DPV UL44 gene. DPV glycoprotein C (DPV-gC) comprises 431 amino acids with a putative molecular mass of 47.35 kDa. Sequence analysis indicated that the protein possesses typical characteristics of type-I membrane glycoproteins, containing an N-terminal signal sequence, an external domain, a C-terminal membra...

Journal: :Intervirology 2009
Ming-Sheng Cai An-Chun Cheng Ming-Shu Wang Li-Chan Zhao De-Kang Zhu Qi-Hui Luo Fei Liu Xiao-Yue Chen

OBJECTIVE The aim was to identify the codon usage bias between the newly identified duck plague virus (DPV) UL35 gene (GenBank accession No. EF643558) and the UL35-like genes of 27 other reference herpesviruses. METHODS A comparative analysis of the codon usage bias of the 28 herpesviruses was performed by using the CodonW 1.4 program and CUSP (create a codon usage table) program of EMBOSS (T...

2012
Qin HE Mingshu WANG Anchun CHENG Dekang ZHU Xiaoyue CHEN Renyong JIA Qihui LUO Yi ZHOU Zhengli CHEN

In this paper, we analyzed the UL43 gene of duck plague virus (DPV) of codon usage bias. The results may provide a basis for understanding the evolution and pathogenesis of DPV and for selecting appropriate host expression systems to improve the expression of target gene in vitro. In this study, the synonymous codon usage bias of UL43 gene in the 24 herpesviruses have been analyzed and the resu...

Journal: :Computer methods and programs in biomedicine 2002
Matthias Grabert Franz Schweiggert Reinhard W. Holl

The DPV approach for quality management and documentation of diabetes in Germany consists of three basic modules: the diabetes documentation software DPV, semi-annual benchmarking for diabetes units (QC-DPV), and a data pool for diabetes research (DPV-SCIENT). The documentation system is available for general practices as well as for hospitals, and it supports the daily routine work of the diab...

Journal: :Journal of acquired immune deficiency syndromes 2015
Beatrice A Chen Lori Panther Mark A Marzinke Craig W Hendrix Craig J Hoesley Ariane van der Straten Marla J Husnik Lydia Soto-Torres Annalene Nel Sherri Johnson Nicola Richardson-Harman Lorna K Rabe Charlene S Dezzutti

BACKGROUND Variable adherence limits effectiveness of daily oral and intravaginal tenofovir-containing pre-exposure prophylaxis. Monthly vaginal antiretroviral rings are one approach to improve adherence and drug delivery. METHODS MTN-013/IPM 026, a multisite, double-blind, randomized, placebo-controlled trial in 48 HIV-negative US women, evaluated vaginal rings containing dapivirine (DPV) (2...

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