To better understand the influence of cholesterol (CH) on dipalmitoylphosphatidylethanolamine (DPPE), Langmuir-Blodgett (LB) model membranes of DPPE with varying amounts of cholesterol were imaged by time-of-flight secondary ion mass spectrometry (ToF-SIMS) and atomic force microscopy (AFM). Cholesterol has a condensing effect on DPPE that at low cholesterol concentrations results in lateral he...

Bis(diphenylphosphine)ethane (DPPE) and its bis[chlorogold(I)] [DPPE(Au2Cl2)], and bis[trichlorogold(III)] [DPPE(Au2Cl6)], complexes have in vivo antitumor activity. To determine if interaction with metals in situ can play a role in the antitumor activity of DPPE, we have studied the effects of DPPE, DPPE(Au2Cl2), DPPE(Au2Cl6) and mixtures of DPPE with metal salts on in vitro and in vivo biolog...

Activation of [FeCl(dppe)Cp] (1) by chloride abstraction with Na[BArX4] (X = F, [B(3,5-(CF3)2-C6H3)4]; X Cl, [B(3,5-Cl2-C6H3)4]) permits reactions a range nitro aromatics, RC6H4NO2 (R halogen, Me, OMe, NO2 or NMe2), to give the cationic iron nitroso complexes [Fe{N(O)-C6H4R}(dppe)Cp][BArX4]) ([3][BArX4]). Similar 1 and [Fe(NCC6H4NO2)(dppe)Cp][BArX4] gave bimetallic [{Fe(dppe)Cp}2{?-N?CC6H4N(O)}...

N,N-Diethyl-2-[(4-phenylmethyl)-phenoxy]ethanamine hydrochloride (DPPE) is a novel paradiphenylmethane derivative with antiproliferative and antiestrogenic properties. Like tamoxifen (TAM), DPPE binds to the microsomal antiestrogen binding site with high affinity (Kd approximately 50 nM), but, conversely, not to estrogen receptor or calmodulin. We now demonstrate that DPPE competes for [3H]hist...

hydrogen bonding of dppe with water that surrounded of membrane, plays an important role in permeability ofmembrane that we were presented this matter with analysis of bond angles and torsion angles before and after ofadded water molecules.interaction with water molecules causes some changes in the geometry of dppe which were explained bythe contribution of zwitterionic form of dppe molecule, a...

Treatment of a newly prepared digold(i) complex, [Au2(dppe)(H2msa)2] ([H41]; dppe = 1,2-bis(diphenylphosphino)ethane, msa = thiomalate), with Ni(2+) gave two interconvertible multinuclear complexes, [Ni{Au2(dppe)(msa)2}](2-) ([2](2-)) and [Ni3{Au2(dppe)(Hmsa)2}{Au2(dppe)(msa)2}(MeOH)3] ([3]), dependent on solution acidities.

Hydrogen bonding of DPPE with water that surrounded of membrane, plays an important role in permeability ofmembrane that we were presented this matter with analysis of bond angles and torsion angles before and after ofadded water molecules.Interaction with water molecules causes some changes in the geometry of DPPE which were explained bythe contribution of zwitterionic form of DPPE molecule, a...

In the crystal structure of the title compound, [Cu(2)Br(2)(dppe)(3)]·2CH(3)COCH(3) [dppe is 1,2-bis-(diphenyl-phosphino)-ethane, C(26)H(24)P(2)], the two Cu centers are bridged by a dppe ligand and each metal center carries one chelating dppe unit, with the fourth coordination site available for the Br(-) anion. The mol-ecule is centrosymmetric, with the center of symmetry located between the ...

III. Covalent Coupling of Streptavidin to N-(4-pMaleimidophenyl)-Butyryl Dipalmitoyl Phosphatidvlethanolamine (MPB-DPPE) Liposomes . . . . . . . . . . . 166 A. Synthesis of MPB-DPPE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 166 B. Coupling of Streptavidin to MPB-DPPE Liposomes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .16...