UNLABELLED The translocator protein (18 kDa) (TSPO), formerly known as the peripheral benzodiazepine receptor, is dramatically upregulated under pathologic conditions. Activated microglia are the main cell type expressing the TSPO at sites of central nervous system pathology. Radioligands for the TSPO can therefore measure active disease in the brain. This article details the synthesis, radiofl...

Objective: The purpose of this study was to compare the treatment effects of a double-plate appliance (DPA) and a double-plate appliance and facemask combination (DPA-FM) in correcting Class III malocclusions. Materials and Methods: The material consisted of lateral cephalometric radiographs of 40 children with skeletal and dental Class III malocclusion. In the first treatment group, 13 patient...

Abscisic acid (ABA), indole-3-acetic acid (IAA) and six cytokinins in wheat (Triticum aestivum L.) grain components were extracted, from 0 to 25d post anthesis (DPA), and quantified by noncompetitive indirect ELISA. At 3 DPA, which coincides with early embryo and endosperm cell divisions, whole kernel hormone levels in μmolkg–1 dry mass (DM) were: zeatin (Z) 30, IAA 4, zeatin riboside 1.8, ABA ...

Spores of Bacillus subtilis spoVF strains that cannot synthesize dipicolinic acid (DPA) but take it up during sporulation were prepared in medium with various DPA concentrations, and the germination and viability of these spores as well as the DPA content in individual spores were measured. Levels of some other small molecules in DPA-less spores were also measured. These studies have allowed th...

NMDA receptor (NMDAR) antagonists are dissociative anesthetics, drugs of abuse, and are of therapeutic interest in neurodegeneration and neuropsychiatric disease. Many well-known NMDAR antagonists are positively charged, voltage-dependent channel blockers. We recently showed that the hydrophobic anion dipicrylamine (DPA) negatively regulates GABA(A) receptor function by a mechanism indistinguis...

Resolution of inflammation is now held to be an active process where autacoids promote homeostasis. Using functional-metabololipidomics and in vivo systems, herein we report that endogenous n-3 docosapentaenoic (DPA) acid is converted during inflammation-resolution in mice and by human leukocytes to novel n-3 products congenerous to D-series resolvins (Rv), protectins (PD) and maresins (MaR), t...