the histone-like protein hu is the most-abundant dna-binding protein in bacteria. the hu protein non-specifically binds and bends dna as a hetero- or homodimer, and can participate in dna supercoiling and dna condensation. it also takes part in dna functions such as replication, recombination, and repair. hu does not recognize any specific sequences but shows a certain degree of specificity to ...

The histone-like protein HU is the most-abundant DNA-binding protein in bacteria. The HU protein non-specifically binds and bends DNA as a hetero- or homodimer, and can participate in DNA supercoiling and DNA condensation. It also takes part in DNA functions such as replication, recombination, and repair. HU does not recognize any specific sequences but shows a certain degree of specificity to ...

Deoxyribonucleic acid (DNA) is an important molecular target for anti-cancer agents due to its involvement in gene expression and protein synthesis which are fundamental steps in cell division and growth. A number of antineoplastic agents interfere with DNA and hence disturb the cell cycle. Compounds including planar aromatic rings are privileged scaffolds in binding to the DNA. This characteri...

Deoxyribonucleic acid (DNA) is an important molecular target for anti-cancer agents due to its involvement in gene expression and protein synthesis which are fundamental steps in cell division and growth. A number of antineoplastic agents interfere with DNA and hence disturb the cell cycle. Compounds including planar aromatic rings are privileged scaffolds in binding to the DNA. This characteri...

a novel ternary schiff base ligand (hl) of ono type and its copper (ii) complex weresynthesised using 2-aminophenol and o-acetoacetotoluidide. they have been characterised by theusual analytical and spectral methods. the interaction of the complex with calf-thymus (ct)dna has been investigated by uv-vis, viscosity measurement, cyclic voltammetry anddifferential pulse voltammetry studies. the re...

background: recent research on several dna fragments covering open reading frames (orf) 1-37 shows a new genetic marker in orf 6 which is specific for differentiating wild-type varicella-zoster virus (vzv) strains from oka varicella vaccine strain. on the other hand, herpes simplex virus (hsv) genome analysis by restriction enzymes is used to differentiate types one and two of the virus and eve...

Lactoferrin (Lf) is an iron-binding multi-functional glycoprotein which has numerous physiological functions such as iron transportation, anti-microbial activity and immune response. In this study, different in silico approaches were exploited to investigate Lf protein properties in a number of mammalian species. Results showed that the iron-binding site, DNA and RNA-binding sites, signal pepti...

In the course of various biological processes, specific DNA-binding proteins must efficiently find a particular target sequence/protein or damaged site on DNA. perform this task based diffusion. Nevertheless, investigations over recent decades have found that diffusion dynamics are generally complicated and, further, protein specific. review, we collect experimental and theoretical studies quan...