Gene polymorphism refers to a variation in DNA sequence that occurs population with frequency of 1% or higher. Polymorphism may be single nucleotide (SNP) some repetitive sequences (length polymorphism). Several methods can used analyze polymorphism, included Polymerase Chain Reaction (PCR), sequencing from the conventional method more sophisticated such as Next Generation Sequencing (NGS), flu...

the aim of this study was to analyze 22 cytokine polymorphisms in the roma population from the republic of macedonia. the roma population consists of 77 healthy unrelated individuals, residents of different geographical regions of the republic of macedonia (skopje, gostivar, and kochani). blood samples were collected after obtaining written consent. dna was isolated from peripheral blood and 22...

background: the aim of this study was to understand any association between differentiated thyroid carcinoma (dtc) and ile3434thr xrcc7 gene polymorphism (genbank accession number: rs7830743). dtc is the most prevalent thyroid neoplasm, which includes papillary and follicular cell carcinoma. xrcc7 gene encodes a protein that functions in non-homologous end joining dna repair pathway. non-synony...

the present study aimed to evaluate the antimicrobial activity of a hetroalkyl oximec synthetic compoundderivative (benzophenone o-4-bromoethyl oxime) against two gram positive and three gram negative bacteria.the antibacterial characteristic of this compound was shown using the circular zone diameter of bacterial growthinhibition by disk-diffusion method. in addition, the random amplified poly...

Background: Indirect genetic diagnosis using polymorphic DNA markers can detect carriers of hemophilia A. This technique is preferable in developing countries because of its simplicity and cost effectiveness compared to direct mutation analysis. In the present study, we examined usefulness of intragenic marker BclI restriction fragment length polymorphism (RFLP) at intron 18, for carrier detect...

background: indirect genetic diagnosis using polymorphic dna markers can detect carriers of hemophilia a. this technique is preferable in developing countries because of its simplicity and cost effectiveness compared to direct mutation analysis. in the present study, we examined usefulness of intragenic marker bcl i restriction fragment length polymorphism (rflp) at intron 18, for carrier detec...

objective: people are usually susceptible to carcinogenic aromatic amines, present in cigarrette smoke and polluted environment, which can cause dna damage. therefore, maintenance of genomic dna integrity is a direct result of proper function of dna repair enzymes. polymorphic diversity could affect the function of repair enzymes and thus augment the risk of different cancers. xeroderma pigment...