UNLABELLED Domain mapping of disease mutations (DMDM) is a database in which each disease mutation can be displayed by its gene, protein or domain location. DMDM provides a unique domain-level view where all human coding mutations are mapped on the protein domain. To build DMDM, all human proteins were aligned to a database of conserved protein domains using a Hidden Markov Model-based sequence...

Sorption-desorption kinetics play a major role in transport and bioavailability of pollutants in soils. Contaminant concentration is a potentially important factor controlling kinetics. A previous paper dealt with the effect of solute concentration on fractional uptake rates of phenanthrene and pyrene from a finite aqueous source. In this study we determined the effect of initial phenanthrene s...

Firms spend high sums trying to make their “home” page as memorable as possible to attract repeat visits. For this purpose, fancy pictures and words are used to catch the attention of visitors. Interestingly, the effectiveness of all of this effort is nearly completely unknown. This study investigated how picture and word selections affected the recognition success rates of the sites visited by...

In this part of a series of review articles on formaldehyde-releasers and their relationship to formaldehyde contact allergy, formaldehyde-releasers in cosmetics are discussed. In this first part of the article, key data are presented including frequency of sensitization and of their use in cosmetics. In Europe, low frequencies of sensitization have been observed to all releasers: 2-bromo-2-nit...

Abstract Rosemary Oil ( Rosmarinus officinalis ) contains carnosic acid, carnosol, and rosmarinic which are sources of active antioxidants. The Secretome MSC has growth factors such as antioxidants that protect HDFs. This study aimed to obtain a gel formulation from secretome combinates with test its effect an antioxidant. antioxidant, propylene glycol humectants, Carbomer 940 gelling agent, tr...

In this study, we report the biochemical characterization of the deafness-associated mitochondrial 12S rRNA C1494T mutation using 27 cybrid cell lines constructed by transferring mitochondria from 9 lymphoblastoid cell lines derived from a Chinese family into human mitochondrial DNA (mtDNA)-less (rho degrees) cells. Six cybrids derived from two asymptomatic members, and nine cybrids derived fro...

BACKGROUND Preservatives present in cosmetics and other industrial products can cause allergic contact dermatitis. The aim of the study was to assess the frequency of allergy to selected preservatives in consecutive patients examined due to contact dermatitis in the Nofer Institute of Occupational Medicine, Łódź, and to establish whether individuals sensitized to formaldehyde react simultaneous...