نتایج جستجو برای: DBC2 Protein

تعداد نتایج: 1234688  

Journal: :Journal of molecular biology 2006
Faith K Chang Noriko Sato Noriko Kobayashi-Simorowski Takashi Yoshihara Jennifer L Meth Masaaki Hamaguchi

DBC2 is a tumor suppressor gene linked to breast and lung cancers. Although DBC2 belongs to the RHO GTPase family, it has a unique structure that contains a Broad-Complex/Tramtrack/Bric a Brac (BTB) domain at the C terminus instead of a typical CAAX motif. A limited number of functional studies on DBC2 have indicated its participation in diverse cellular activities, such as ubiquitination, cell...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Masaaki Hamaguchi Jennifer L Meth Christine von Klitzing Wen Wei Diane Esposito Linda Rodgers Tom Walsh Piri Welcsh Mary-Claire King Michael H Wigler

A previously uncharacterized gene, DBC2 (deleted in breast cancer), was cloned from a homozygously deleted region at human chromosome 8p21. DBC2 contains a highly conserved RAS domain and two putative protein interacting domains. Our analyses indicate that DBC2 is the best candidate tumor suppressor gene from this region. It lies within the epicenter of the deletions and is homozygously deleted...

2014
Jacob R. Manjarrez Liang Sun Thomas Prince Robert L. Matts

The expression of the wild-type tumor-suppressor gene DBC2 (Deleted-in-Breast Cancer 2, a.k.a RhoBTB2) is suppressed in many cancers, in addition to breast cancer. In a screen for Cdc37-associated proteins, DBC2 was identified to be a potential client protein of the 90 kDa heat shock protein (Hsp90) chaperone machine. Pull down assays of ectopically expressed DBC2 confirmed that DBC2 associated...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2012
Wei Dong Long Meng Hong-Chang Shen Jia-Jun Du

PURPOSE DBC2 (Deleted in Breast Cancer 2) has been indicated to be a tumor suppressor gene in many cancers including lung adenocarcinoma recently. In this study, we aimed to explore the expression status of DBC2 in different subtypes of lung adenocarcinoma (from pre-invasive to invasive lesions), and to determine if downregulation becomes more marked with pathological progression. METHODS We ...

Journal: :iranian journal of pathology 2014
fahimeh mousavi mehrdad noruzinia elahe keyhani feridoon seirati samira rezaei

background and objective: the dbc2 (deleted in breast cancer 2) or rhobtb2 (located on 8p21) is a tumor suppressor gene associated with tumorigenesis. mutational studies of dbc2 at its promoter region in breast cancer revealed an important role for epigenetic changes contributing to its low expression. epigenetic changes through hypermethylation of the promoter can cause the inactivation of dbc...

2012
Mehri Hajikhan Mirzaei Mehrdad Noruzinia Hamid Karbassian Yousef Shafeghati Mousa Keyhanee Ali Bidmeshki-Pour

OBJECTIVE Breast cancer is one of the most common malignancies in women worldwide. It is caused by a number of genetic and epigenetic factors. Aberrant hypermethylation of the promoter regions in specific genes is a key event in the formation and progression of breast cancers as well as the DBC2 gene, as a tumor suppressor gene. Different studies show that the DBC2 gene is inactivated through e...

Elahe Keyhani, Fahimeh Mousavi Farkhondeh Behjati, Feridoon Seirati Forough Mojtahedi Mehrdad Noruzinia Samira Rezaei

Background and Objective: The DBC2 (deleted in breast cancer 2) or RhoBTB2 (Located on 8p21) is a tumor suppressor gene associated with tumorigenesis. Mutational studies of DBC2 at its promoter region in breast cancer revealed an important role for epigenetic changes contributing to its low expression. Epigenetic changes through hypermethylation of the promoter can cause the inactivation of DBC...

2012
Wei Dong Long Meng Hong-Chang Shen Jia-Jun Du

Lung cancer is currently the leading cause of cancerrelated death in most Asian countries and the world (Merel Kimman et al., 2012), of which adenocarcinoma accounts for more than 50% of all cases (Pao and Girard, 2011). Lung adenocarcinoma is of diverse subtypes, the new classification includes pre-invasive lesions, minimally invasive adenocarcinoma, invasive adenocarcinoma and some variants (...

Journal: :Biochemical and Biophysical Research Communications 2007

Journal: :International journal of clinical and experimental medicine 2015
Chuan-Jiang Wang Dong Yang Ying-Wei Luo

Thyroid cancer is the most common endocrine malignancy worldwide. Tumor suppressor gene RhoBTB2 (also known as Deleted in Breast Cancer 2, DBC2) was observed in various carcinomas, however, no reports showed the effects of RhoBTB2 on thyroid cancer. In our study, we found that RhoBTB2 decreases proliferation, increases apoptosis, inhibits mobility, and induces mitochondria damage in SW579 cells...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید