نتایج جستجو برای: DAT scan
تعداد نتایج: 84182 فیلتر نتایج به سال:
[DaT-SCAN SPECT in the differential diagnosis of dementia with Lewy bodies and Alzheimer's disease].
INTRODUCTION Dementia with Lewy bodies (DLB) is one of the main differential diagnosis of Alzheimer's disease (AD). In DLB there is 40-70% loss of striatal dopamine and the loss of dopaminergic cell is accompanied by loss of the dopamine transporter. The loss of dopaminergic neurons in DLB can be confirmed in vivo with I-FP-CIT (DaT-SCAN), a pre-synaptic dopamine transporter marker. There are n...
Neurology 2012;78:688–689 The Food and Drug Administration (FDA) recently approved [I]ioflupane ([I]-fluoropropyl CIT), a dopamine transporter (DAT) radioligand, for SPECT to “assist in the evaluation of adult patients with suspected parkinsonian syndromes (PS).”1 This permits physicians to prescribe [I]ioflupane SPECT scans as part of clinical practice. Advertisements encourage clinicians to o...
Early and correct diagnosis of Parkinson's disease (PD) is critical for patient counseling and therapeutic management. The diagnostic accuracy of transcranial sonography of substantia nigra (SN-TCS) for early stage PD patients remains controversial. Dopamine transporter (DAT) imaging is sensitive to detect presynaptic dopamine neuronal dysfunction, and has been studied as a diagnostic tool for ...
Dopaminergic therapy in Parkinson's disease (PD) can improve some cognitive functions while worsening others. These opposite effects might reflect different levels of residual dopamine in distinct parts of the striatum, although the underlying mechanisms remain poorly understood. We used functional magnetic resonance imaging (fMRI) to address how apomorphine, a potent dopamine agonist, influenc...
OBJECTIVE Analyze indications for ordering DAT-SPECT scans and the clinical impact of scan results on patients evaluated in a movement disorders practice. BACKGROUND DAT-SPECT is FDA approved to evaluate cases of suspected presynaptic dopaminergic deficiency. Little data is available on clinical use and impact of these scans among movement disorders neurologists. METHODS DAT-SPECT scans ord...
Parkinsonism and attention deficit hyperactivity disorder (ADHD) are widespread brain disorders that involve disturbances of dopaminergic signaling. The sodium-coupled dopamine transporter (DAT) controls dopamine homeostasis, but its contribution to disease remains poorly understood. Here, we analyzed a cohort of patients with atypical movement disorder and identified 2 DAT coding variants, DAT...
Dopamine transporter (DAT) imaging is a valuable tool to aid in the diagnosis of Parkinson disease and other Parkinsonian syndromes. DAT imaging is special among clinical nuclear medicine scans in that the already small caudate and putamen are presented in multiple thin axial cuts. Because the imaged basal ganglia are small, slight differences in head tilt may result in a significant artifact t...
In this article, the role of Dopamine Active Transporter (DAT) scan, and Positron Emission Tomography (PET) scan along with α-synuclein regards to Parkinson’s disease will be discussed. Furthermore, their applications dependence as diagnostic techniques, well biomarkers, are also reviewed. short, DAT-SPECT PET scans can used differentiate between other Parkinsonian syndromes, but it takes exper...
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