Recent experiments have shown that the congener Abeta(1-40)[D23-K28], in which the side chains of charged residues Asp23 and Lys28 are linked by a lactam bridge, forms amyloid fibrils that are structurally similar to the wild type (WT) Abeta peptide, but at a rate that is nearly 1000 times faster. We used all atom molecular dynamics simulations in explicit water, and two force fields, of the WT...

VEGFs activate 3 receptor tyrosine kinases, VEGFR-1, VEGFR-2, and VEGFR-3, promoting angiogenic and lymphangiogenic signaling. The extracellular receptor domain (ECD) consists of 7 Ig-homology domains; domains 2 and 3 (D23) represent the ligandbinding domain, whereas the function of D4-7 is unclear. Ligand binding promotes receptor dimerization and instigates transmembrane signaling and recepto...

VEGFs activate 3 receptor tyrosine kinases, VEGFR-1, VEGFR-2, and VEGFR-3, promoting angiogenic and lymphangiogenic signaling. The extracellular receptor domain (ECD) consists of 7 Ig-homology domains; domains 2 and 3 (D23) represent the ligand-binding domain, whereas the function of D4-7 is unclear. Ligand binding promotes receptor dimerization and instigates transmembrane signaling and recept...

-Papain-solubilized tumour-specific antigens from the aminoazo dyeinduced rat hepatoma D23 were purified by a combination of lectin affinity and immunoadsorbent column chromatography. Isolated antigens were radio-iodinated using three procedures and analysed for their reaction with specific antibodies in syngeneic immune sera by double-antibody co-precipitation tests and by the rebinding of lab...

Complement-dependent cytotoxicity in tumor bearer sera (TBS) from Wistar rats carrying any of five transplantable aminoazo dye-induced hepatomas (D23, D33, D23/Not, D30, or D202) were investigated by a short-term 51Cr release assay. Extensive tests of various TBS against the hepatomas revealed that the tumors could be divided into two groups. Group 1 hepatomas (D23, D33, and D23/Not) all shared...

The position of singular lines for orthorhombic (ORT) media with fixed diagonal elements the elasticity matrix cij, i=1…6 is studied under condition that c11, c22, c33>c66>c44>c55. In this case, off-diagonal coefficients c12, c13, c23 are chosen so some values d12=c12+c66, d13=c13+c55, d23=c23+c44 zero. For medium, where only one d12, d13, d23 zero, contains points in planes symmetry. ...

A detailed analysis of the NMR spectra of amyloid-β (Aβ) peptide revealed a decrease in signal intensity at higher temperature, due to a reversible conformational change of the molecule. Although peak intensity did not depend on peptide concentrations, the intensity in the region from D23 to A30 depended significantly on temperature. During the early stages of Aβ aggregation, each molecule migh...

1. Abstract 2. Introduction 3. Methods and materials 3.1. MD simulations 3.2. Calculations of intramolecular contacts 3.3. Identification of a reverse loop 3.4. Identification of the SLS 3.5. Conformational Clustering 4. Results 4.1. The simulations are close to equilibrium and the results are consistent with NMR experiments 4.2. The analysis of overall topologies reveals that the WT favors Loo...