cystatin c is a 13 kd basic protein that is a member of the cystatin superfamily of cysteine protease inhibitors. the cystatin c gene seems to be a house keeping gene, which is compatible with a stable production rate of cystatin c by most cells. this protein is freely filtered through the glomerulus and almost completely reabsorbed and catabolized by proximal tubular cells. because of these ch...

Background: Accurate and rapid assessment of allograft function is essential in renal transplant recipients in order to detect allograft rejection and to monitor drug nephrotoxicity. We aimed to evaluate the usefulness of cystatin C as a marker of kidney allograft function in the early post-transplant period and to compare this value with that of conventional serum creatinine concentration. Met...

background: accurate and rapid assessment of allograft function is essential in renal transplant recipients in order to detect allograft rejection and to monitor drug nephrotoxicity. we aimed to evaluate the usefulness of cystatin c as a marker of kidney allograft function in the early post-transplant period and to compare this value with that of conventional serum creatinine concentration.   m...

Background: Hypertension is one the most common causes of chronic kidney disease (CKD). One of the major concerns in hypertensive patients is early detection of renal disorders. In the past, serum creatinine (Scr) concentration was used as a marker of kidney function, but it proffers a late reflection of reduced glomerular filtration rate. Cystatin C and neutrophil gelatinase-associated lipocal...

background: polycystic ovary syndrome (pcos) causes an increased risk of metabolic cardiovascular syndrome. also, cystatin c serum levels are associated with the risk of cardiovascular events in metabolic syndrome patients. objective: to investigate the relationship between cystatin c in pcos patients. materials and methods: 35 women with pcos were compared to 35 women with healthy matched age ...

background serum creatinine as a classic marker of renal function has several limitations in the detection of renal dysfunction. objectives this study assessed the validity of serum cystatin c as a marker of renal function in critically ill patients with normal serum creatinine. patients and methods eighty adult patients referred to intensive care units with serum creatinine levels < 1.5 mg/dl ...

Cystatin C is a 13 KD basic protein that is a member of the cystatin superfamily of cysteine protease inhibitors. The cystatin C gene seems to be a house keeping gene, which is compatible with a stable production rate of cystatin C by most cells. This protein is freely filtered through the glomerulus and almost completely reabsorbed and catabolized by proximal tubular cells. Because of the...

background glomerular filtration rate (gfr) is widely estimated by serum creatinine based equations such as cockcroft-gault (cg) standardized for body surface, and an abbreviated formula derived from mdrd (modification of diet in renal disease) study. however, some studies suggested that creatinine based estimation of gfr formula can be replaced by cystatin c based formula. objectives the aim o...