Flavonoids with potent anti-oxidative effects are the major effective components in traditional herbal medicine used in treating cardiovascular diseases. Cynaroside is a flavonoid compound that exhibits anti-oxidative capabilities. However, little is known about its effect on oxidative injury to cardiac myocytes and the underlying mechanisms. This study was designed to investigate the protectiv...

Aim to develop a methodology for qualitative and quantitative analysis of flavonoids in the herb Achillea millefolium L.
 Material methods. The material study was yarrow harvested 2020 2021, an industrial sample from JSC "Krasnogorskleksredstva". Additionally, we used reference samples flavonoids: rutin, quercetin, kaempferol, cynaroside, luteolin, received previously during our studies ra...

Monoamine oxidase inhibitors (MAOI) have been widely used as antidepressants. Recently, there has been renewed interest in MAO inhibitors. The activity-guided fractionation of extracts from Angelica keiskei Koidzumi (A. keiskei K.) led to the isolation of two prenylated chalcones, xanthoangelol and 4-hydroxyderricin and a flavonoid, cynaroside. These three isolated compounds are the major activ...

From the flowers of Carthamus tinctorius L., cultivated in Samara Region (Russian Federation) there was isolated a new flavonoid, named us saffloroside, which has the structure of 7-О--Dglucopyranoside of 3, 7, 31, 41-tetrahydroxy-5-methoxyflavone (azaleatin). The chemical structure of saffloroside there was elucidated by means of 1H-NMR-, UV-spectroscopy and mass spectrometry. In the course o...

Transthyretin (TTR) is a homotetrameric plasma protein with amyloidogenic properties that has been linked to the development of familial amyloidotic polyneuropathy (FAP), familial amyloidotic cardiomyopathy, and senile systemic amyloidosis. The in vivo role of TTR is associated with transport of thyroxine hormone T4 and retinol-binding protein. Loss of the tetrameric integrity of TTR is a rate-...

Introduction. Alchemilla herb is proposed for introduction into pharmaceutical practice, obtaining extracts with various pharmacological activity. To expand, resource base of it has been to use a high biomass cultivated plant – mollis (Buuser) Rothm. In terms qualitative and quantitative characteristics the chemical composition comparable samples raw materials wild-growing . The presence chemot...

OBJECTIVES The aim of this study was to investigate the flavonoid composition of Scutellaria immaculata and S. ramosissima (Lamiaceae) and the in-vitro biological activity of their extracts and flavonoids. METHODS The flavonoid composition of S. immaculata (Si) and S. ramosissima (Sr) were analysed using LC-MS. Antimicrobial activity was studied in vitro against a range of bacteria and fungi ...