Malignant pleural mesothelioma is a poorly treated neoplasia arising from the pleural mesothelial lining. Here we document that the leaf extract of Cynara scolymus exerts broad antitumoral effects both in vitro and in vivo on mesothelioma cell lines. We found that Cynara scolymus treatment affects strongly cell growth, migration and tumor engraftment of mesothelioma cell lines. Strikingly, diet...

Background. Based on recent basic and clinical investigations, the extract of artichoke (Cynara scolymus) leaf has been revealed to be used for hepatoprotective and cholesterol reducing purposes. We aimed to assess the therapeutic effects of artichoke on biochemical and liver biomarkers in patients with nonalcoholic steatohepatitis (NASH). Methods. In a randomized double blind clinical trial, 6...

Cynara genus, originating from the Mediterranean area, includes globe artichoke (Cynara cardunculus var. scolymus L) and cardoon (Cynara cardunculus var. altilis DC). Traditionally these crops have long been used as food and medicine. Nowadays, they are considered as functional foods, owing to their nutritional properties. Artichoke has exhibited hepatoprotective and antioxidative activities, a...

The artichoke (Cynara cardunculus L. subsp. scolymus L.), the cultivated cardoon (Cynara cardunculus var. altilis DC.) and the wild cardoon (Cynara cardunculus var. sylvestris L.) are species widely distributed in the Mediterranean area. The aim of this research was to evaluate the antioxidant properties of seeds from lines of artichoke and cultivated and wild cardoon in both aqueous-organic ex...

The artichoke by-products from the canning industry are mainly used for silage, being minimally revaluated. The ways of extraction of by-products of artichoke into fiber-rich powders modify their industrial applications in biscuits, as the sensory evaluation may change compared with the reference fiber (Pea fiber, P) used with commercial biscuit. In this sensory study biscuits enriched with fib...

Because weevils are used as biocontrol agents against thistles, it is important to document and understand host shifts and the evolution of host-specificity in these insects. Furthermore, such host shifts are of fundamental interest to mechanisms of speciation. The mediterranean weevil Larinus cynarae normally parasitizes either one of two thistle genera, Onopordum and Cynara, being locally mon...

Two field experiments were carried out during the winter seasons of 2000/2001 and 2001/2002 at the Agricultural Experimental Station (at Abeis) Alexandria University, to investigate the response of globe artichoke plants cv. French, to the inoculation with Halex2 and Microbein biofertilizers under varying N levels (0, 45, 90 and 135 kg N fed -1 ). The results indicated that increasing N applied...

Cynara cardunculus.L exhibits an important adaptability to arid and semi-arid regions where high salinity is frequently present. Aiming to introduce its cultivation in the Mediterranean environment especially in Tunisia, it seemed interesting to study seed germination of eight populations of cardoon in four concentrations of NaCl: 0g/L, 2g/L, 4g/L, and 8g/L. Our results showed a good variabilit...

Cynara scolymus L. is a medicinal plant frequently used in traditional medicine for liver diseases. The aim of this study is to evaluate the antimicrobial activity of the different parts of Artichoke. Maximum antimicrobial activity was observed with methanolic extract of bound phenols for (bract and heart) against Gram negative bacteria. The MIC values for bound phenols from heart were (63μg/ml...

Effect of Methanol and Titanium Dioxide Nanoparticles on Phytochemical Properties Artichoke (Cynara scolymus L.)