نتایج جستجو برای: Cyclin D1 Gene
تعداد نتایج: 1164953 فیلتر نتایج به سال:
Objective(s): Hepatocellular carcinoma (HCC) is one of the most significant health condition around the world. As the only curative therapies, liver transplantation and surgical resection are the clinical treatments of HCC. Due to the systemic toxicity and severe side effects of these treatments, it is vital to establish new therapeutic approaches. The present study ai...
Background: The use of medicinal herbs in traditional medicine has been important and many of these plants have antioxidant, anti-inflammatory, antimicrobial and anti-cancer effects. Objective: The aim of this study was to evaluate the antibacterial and anti-cancer effects of Artemisia turcomanica extract on gastric cancer cell line (AGS) and its effect on expression of cyclin D1 and cyclin E g...
Background: Researchers argue that supplements are somewhat capable of influencing the lung tissue exposed to smoking carcinogens through cell cycle. Cyclin D1 is a gene involved in cell cycle. Objective: This study aimed to investigate the effects of 12-week injection of Nigella sativa nano-capsule on the expression of Cyclin D1 of the lung tissue of the rats receiving exposure to Nicotine-Der...
background and objective: clinical behavior of basal cell carcinoma (bcc) is known to be different according to histological growth pattern and basosquamous cell carcinomas (bsc) are known with their aggressive behavior and metastatic capacity. in this study, we evaluated bcl-2 and cyclin d1 expressions in bcc and bsc cases comparatively, to explore their predictive value on the aggressive beha...
background: esophageal squamous cell carcinoma (escc) is one of the lethal cancers with a high incidence rate in asia. many genes including cyclin d1 and p16 play important role in its carcinogenesis. we aimed to analyze the expressions of cyclin d1 and p16 with the various clinicopathological characteristics of escc. method: we examined 30 biopsy samples of escc for cyclin d1 and p16 protein...
The CCND1 gene, which is frequently overexpressed in cancers, encodes the regulatory subunit of a holoenzyme that phosphorylates the retinoblastoma protein. Although it is known that cyclin D1 regulates estrogen receptor (ER)α transactivation using heterologous reporter systems, the in vivo biological significance of cyclin D1 to estrogen-dependent signaling, and the molecular mechanisms by whi...
Background: Zearalenone (ZEA) is known as a nonsteroidal oestrogenic mycotoxin produced by different species of Fusarium fungi. ZEA is known for its competitive effects with the natural 17-β estradiol to bind with the specific binding sites of the estrogen receptors (Ers). On the other hand, the cyclin family (especially cyclin D1) and E2F1 genes are the checkpoint genes involved in cell cycle....
background and objective: esophageal cancer especially squamous cell carcinoma (scc) is one of the most common gastro intestinal malignancies in north part of iran (khorasan). the standard treatment for esophageal cancer is surgical resection, but its outcome remains poor. then, the oncologists try to treat this cancer with sandwich protocols especially neo-adjuvant chemo-radiotherapy. several ...
Background: Hepatocellular carcinoma is the most common primary malignant tumor of the liver. The effect of some genes especially those involved in cell cycle regulation have been shown in the development of this cancer in several studies but there are some controversies about them yet. Materials and methods: The paraffin-embedded tissue samples of 25 patients (18 males and 7 females) with hep...
Cyclin D1 overexpression is believed to be essential in the pathogenesis of mantle cell lymphoma (MCL). Hence, the existence of cyclin D1-negative MCL has been controversial and difficult to substantiate. Our previous gene expression profiling study identified several cases that lacked cyclin D1 expression, but had a gene expression signature typical of MCL. Herein, we report the clinical, path...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید