Cyclamen coum is a traditional medicinal plant in the Turkey. Its anticancer properties and whether cyclamen extract induces any cytotoxicity in solid cancer cell lines have not been thoroughly investigated previously. Therefore we examined cytotoxic effects on cervical cancer, HeLa, and non small cell lung cancer cell, H1299, lines. Cyclamen extract induced cellular death of both HeLa and H129...

BACKGROUND Biofilm formation is a major pathogenic factor in different bacteria such as Pseudomonas aeruginosa. A number of studies have reported that bacterial biofilms show different levels of antibiotic resistance. In order to re-sensitize the bacterial biofilms to antibiotics, biofilms should be dispersed. OBJECTIVES In this study, the effect of n-butanolic Cyclamen coum extract in combin...

conclusions: using n-butanolic c. coum extract in combination with ciprofloxacin offers a novel strategy to control biofilm-based infections caused by p. aeruginosa. results: the ability of biofilm formation by p. aeruginosa strains was quantitatively confirmed. the pcr method confirmed the existence of cup a gene (172 bp) in all studied strains. saponin content of the n-butanolic c. coum extra...

background and purpose: candidiasis, an important fungal infection, is considered the fourth most common nosocomial blood stream infection. nowadays, because of increased fungal resistance to antibiotics, the use of herbal medicine has gained particular attention. cyclamen species are medicinal plants containing triterpenoid saponins, which are shown to have antimicrobial properties. materials ...

Introduction: Infections caused by Pseudomonas aeruginosa biofilm are the major causes of death in patients with cystic fibrosis (CF). Some studies revealed that biofilms are resistant to several antibiotics because of their impermeable structures. In order to resensitize bacteria to different antibiotics, biofilm formation should be inhibited. In this research, evaluation of antibiofilm activi...