In modern life science research, structural information on proteins is indispensable for understanding the mechanisms of their biological functions. Many protein structures have been determined by X-ray crystallography, which has developed in conjunction with molecular biology experiments and synchrotron radiation development. Since Nobel Prize Chemistry 2017, rapid progress cryo-EM hardware an...

Some new 3-(alkylsulfanyl)- 7-chloro-1-phenyl-1H-pyridazino [4,3-e][1,3,4]thiadiazine were synthesized  by treatment of the alkyl-2-phenylhydrazinecarbodithioates with 4-bromo-3,6-dichloropyridazine in alkaline acetonitril. Orientation of the reaction has been determined by X-Ray crystallography technique. The chlorine atom on the number 7 position of these products was replaced by secondary am...

After more than half a century of evolution, machine learning and artificial intelligence, in general, are entering truly exciting era broad application commercial research sectors. In X-ray crystallography, its to structural biology, is finding home within expert automated systems, forecasting experiment data analysis outcomes, predicting whether crystals can be grown even generating macromole...

The study of crystals at atomic level by electrons - electron crystallography - is an important complement to X-ray crystallography. There are two main advantages of structure determinations by electron crystallography compared to X-ray diffraction: (i) crystals millions of times smaller than those needed for X-ray diffraction can be studied and (ii) the phases of the crystallographic structure...