Objective: To investigate the impact of a Croton tiglium extract on cellular proliferation and apoptosis in a nonsmall cell lung cancer cell line (A549) in vitro. Methods: A Croton tiglium seed methanol extract was prepare and assessed for effects on A549 cells regarding cellular proliferation, apoptotic rates, and expression of apoptosis related genes and proteins using real-time PCR and immun...

Extensive and indiscriminate use of synthetic compounds and natural compounds obtained from plant sources have resulted into serious threats to not only the aquatic ecosystem but also to human health. Aqueous seed extract of the plant Croton tiglium L. is used in many traditional medicines to treat various ailments in many developing countries. The extract is also used for killing fishes for co...

Croton tiglium L. is a traditional medicinal plant grown in tropical and subtropical zone. The extract of seeds is generally used as medicine as they are rich in secondary metabolites, such as, alkaloids, flavonoids, terpenoids and saponins. Plant is used in the treatment of various ailments in developing countries such as wound healing, constipation, a purgative, traditional dyspepsia, dysente...

Toll-like receptor (TLR) ligands are being developed for use as vaccine adjuvants and as immunomodulators because of their ability to stimulate innate and adaptive immune responses. Flagellin, a TLR5 ligand, was reported to show potent mucosal vaccine adjuvant activity. To identify ligands that potentiate the adjuvant activity of flagellin, we screened a plant library using HEK293T cells transi...

(cocarcinogenic) materials labeled A and C from the seeds of Croton tiglium L. were summarized (10, 11). The chemical constitution of a polyhydroxyphenolic ester, m.p. 96°C, obtained by the catalytic hydrogenation of a biologically active fraction and referred to as croton resin, was also described (10). The present report concerns long-term biologic testing of the active materials A and C, th...

the seed of croton tiglium l. (sct) is a well known folk medicine. in china, it has used to treat gastrointestinal disorders, intestinal inflammation, rheumatism, and so on. previous studies established its purgative and inflammation properties. in addition, the effects of essential oil of sct on intestinal transit and gastrointestinal tract has been studied. in the present study, we evaluated ...

Croton tiglium used as a cathartic in Ayurvedic system of indigenous medicine, was investigated for its effects in experimental animals. 50% EtOH extract of the dried nuts of the plant was used of the study. The extract exhibited a dose dependent cathartic effect in albino rats, the extract also showed an increase to gut movement with an increased contractile movement on rabbit jejunum, partial...

1. Proteins extracted from the seeds of the Euphorbiaceae Croton tiglium and Jatropha curcas were separated into three major peaks (I, Hand III) by Sephadex chromatography. 2. The crude protein from both seeds and peaks I and II from Croton and peak I from Jatropha were toxic to mice, to different extents. 3. The crude protein and peak I and peak II from both seeds, inhibited protein synthesis ...