background: several studies reported the clinical features of ige-mediated hypersensitivity after ingestion of melon. melon allergy is a common ige-mediated fruit allergy in iran. this prompted us to investigate immunochemical and molecular properties of the major allergen in melon fruit, to compare the ige-binding capacity of the natural protein with the recombinant allergen, and to determine ...

abstract cisplatin was the first of the platinum drugs. second-generation platinum derivative was carboplatin that its efficacy in the treatment of many malignancies is equal to cisplatin, and its toxicity profile is more favorable. here we report on a 50-year-old woman with a history of cervix cancer who developed a severe hypersensitivity reaction (hsr) to carboplatin. she was admitted to the...

background and objectives : 300 pseudomonas aeruginosa strains were isolated from hospitalized patients in iran. using international antigenic typing system (iats) antibodies, all strains were classified into 16 serotypes while serotype 14 was not identified among the 17 known serotypes. to evaluate the rate of cross-reactivity between o- antigenic determinants, monospecific polyclonal antibodi...

background : antivenom is still widely used in the treatment of envenomation as there are no vaccines or other effective agents available against animal venoms. recently, neurotoxins named birtoxin family have been described from parabuthus transvaalicus and androctonus crassicauda. the aim of the present study was to test the antibirtoxin antibodies for their ability to neutralize the lethal e...

beta-lactams are a group of antibiotics with a broad spectrum of both gram-negative and gram-positive coverage. the goal of this study is to evaluate the results from studies regarding ig-e mediated hypersensitivity to penicillin and cross-reactivity with other beta-lactams. review was conducted of both retrospective and prospective studies by searching in pubmed and medline for the original an...

background: pan-igg specific monoclonal antibodies (mabs) are essential tools for assessment of humoral immunity, immune deficiency and gammopathy. in this study, four hybridoma clones producing mabs with different specificities for human igg isotypes were established. methods: splenocytes from balb/c mice immunized with fc fractions of human igg were fused with sp2/0 myeloma cells. hybridoma c...

the importance of amaranthus retroflexus pollen in causing respiratory allergy has been well ascertained in many countries including iran with a high positive rate (69%) among iranian allergic patients. the aim of the present study is to identify the allergenic properties of a. retroflexus pollen. sixteen patients with allergy to a. retroflexus pollen were selected for the study. the antigenic ...

background: cross antigenicity is the major problem in developing a reliable tool for immunodiagnosis and immunoprophylaxis of parasitic diseases. mixed infection due to different types of gastrointestinal parasites is more common than single species infection under field condition. methods: the present study was undertaken to detect antigenic cross-reactivity among haemonchus contortus, oesoph...

Background: Several studies reported the clinical features of IgE-mediated hypersensitivity after ingestion of melon. Melon allergy is a common IgE-mediated fruit allergy in Iran. This prompted us to investigate immunochemical and molecular properties of the major allergen in melon fruit, to compare the IgE-binding capacity of the natural protein with the recombinant allergen, and to determine ...

Cisplatin was the first of the platinum drugs. Second-generation platinum derivative was carboplatin that its efficacy in the treatment of many malignancies is equal to cisplatin, and its toxicity profile is more favorable. Here we report on a 50-year-old woman with a history of cervix cancer who developed a severe hypersensitivity reaction (HSR) to carboplatin. She was admitted to the emergenc...