Introduction: Polyethylene wear particles induce macrophages to release cytokines, which can lead to osteolysis and aseptic loosening of total joint prostheses. The generation of polyethylene wear particles is one of the most important factors that affect the midterm and long-term clinical results associated with total knee arthroplasty (TKA). Therefore, to achieve better long-term results for ...

Cross-linked polyethylene has been explored as an alternative to conventional polyethylene in total joint replacement in order to reduce wear volume and decrease failure through polyethylene wear debris induced osteolysis [1]. Due to the demands of a total knee replacement, moderately cross-linked polyethylene is recommended to retain mechanical properties [2]. This study aims to investigate th...

The creep and wear behaviour of highly cross-linked polyethylene and standard polyethylene liners were examined in a prospective, double-blind randomised, controlled trial using radiostereometric analysis. We randomised 54 patients to receive hip replacements with either highly cross-linked polyethylene or standard liners and determined the three-dimensional penetration of the liners over three...

UNLABELLED Wear particle-induced osteolysis is a major cause of aseptic loosening in THA. Increasing wear resistance of polyethylene (PE) occurs by increasing the cross-link density and early reports document low wear rates with such implants. To confirm longer-term reductions in wear we compared cross-linked polyethylene (irradiation in nitrogen, annealing) with historical polyethylene (irradi...

The objective of our study was to evaluate the influence of prolonged artificial ageing on oxidation resistance and the subsequent wear behaviour of vitamin E-stabilized, in comparison to standard and highly cross-linked remelted polyethylene (XLPE), and the degradation effect of third-body particles on highly cross-linked remelted polyethylene inlays in total hip arthroplasty. Hip wear simulat...

We conducted a systematic review and meta-analysis of randomised controlled trials comparing cross-linked with conventional polyethylene liners for total hip replacement in order to determine whether these liners reduce rates of wear, radiological evidence of osteolysis and the need for revision. The MEDLINE, EMBASE and COCHRANE databases were searched from their inception to May 2010 for all t...

Cross-linked polyethylenes are being marketed by orthopaedic manufacturers to address the problem of osteolysis caused by polyethylene particulate wear debris. Wear testing of these cross-linked polyethylenes in hip simulators has shown dramatic reduction in wear rate compared with standard ultrahigh molecular weight polyethylene, either gamma irradiated in air or nitrogen - or ethylene oxide-s...

+*Jennings, L M; *Galvin, A L; *Fisher J +Institute of Medical & Biological Engineering, Leeds, UK [email protected] Introduction There is increasing interest in the coupling of highly cross-linked polyethylene with large diameter heads in the hip, due to the reported lower wear characteristics of highly cross-linked polyethylene compared to conventional polyethylene [1, 2, 3]. Further, ...

Cross linking of high density polyethylene (HDPE) was first performed via high energy10 Mev electron beam (EB) irradiation. HDPE was also cross linked withDicumyle peroxide (DCP).The gel content of samples was determined by solvent extraction.Degree of cross linking was evaluated by hot set apparatus; as well .In order to clarify the effectof nature of cross linking, correlation of electrical p...

Introduction It is well known that the wear resistance of ultra-high molecular weight polyethylene (UHMWPE) improves in proportion to the crosslinking irradiation dose. It is also well known that the mechanical properties and oxidative stability of UHMWPE are affected by the irradiation dose, resin type, and post-irradiation heat treatment, among others factors. Therefore, careful consideration...