statement of problem: changes in protein levels, host calls enzymes and inflammatory mediators in gingival crevicular fluid (gcf) are considered as diagnostic indicators of periodontitis.purpose: he aim of the present study was to measure the elastase enzyme activity in gingival crevicular fluid among patients with periodontitis.material and methods: in this study, 52 periodontitis patients (ex...

interleukin-1β (il-1β) is one of the most important cytokines which seems to have an important role in the inflammatory process in gingival and peri-implant tissues. the aim of this split-mouth study was to investigate the relationship between the concentration of il-1β in gingival crevicular fluid (gcf) and peri-implant crevicular fluid (picf) and clinical parameters such as plaque index (pi),...

Background: Receptor activator of nuclear factor kappa B ligand (RANKL) is one of the key cytokines in the induction of osteoclastogenesis both in vitro and in vivo.Several reports indicated the presence of sRANKL in gingival crevicular fluid of patients with periodontal diseases. Objective: To determine the presence of RANKL in peri-implant crevicular fluid samples of implants with peri-implan...

background: receptor activator of nuclear factor kappa b ligand (rankl) is one of the key cytokines in the induction of osteoclastogenesis both in vitro and in vivo.several reports indicated the presence of srankl in gingival crevicular fluid of patients with periodontal diseases. objective: to determine the presence of rankl in peri-implant crevicular fluid samples of implants with peri-implan...

objective: the gingival crevicular fluid (gcf) is an inflammatory exudate found in the gingival sulcus. the forces exerted during orthodontic treatment cause distortion of the periodontal ligament (pdl) extra-cellular matrix, resulting in some biological features that can lead to modification of both gcf volume and its components. the present study investigated the effect of orthodontic tooth m...

BACKGROUND AND OBJECTIVE Emdogain (EMD), consisting mostly of amelogenin, is used in periodontal therapy to regenerate lost connective tissue. Emdogain is applied onto periodontally affected root surfaces, where it becomes exposed to proteolytic enzymes. In this study, we aimed to find out whether gingival crevicular fluid or matrix metalloproteinases (MMPs) could degrade EMD, and whether this ...

Our studies aimed the eventual correlations of chemokines and interleukins levels (IFN-γ, IL-10, IL-2, IL-4, IL-5 and TNF-α) in serum and gingival crevicular fluid of patients with periodontitis and juvenile insulindependent diabetes mellitus as compared to periodontal healthy subjects (32 vs. 24 children and adolescents, respectively). The diabetic body interferences with microbiological micro...

Neutrophil collagenase (matrix metalloproteinase 8 [MMP-8]) is an important mediator of tissue destruction in inflammatory diseases. Studies of anaerobic periodontal infections have shown that active MMP-8 in gingival crevicular fluid is associated with the degradation of periodontal tissues in progressive periodontitis whereas the latent enzyme is predominant in gingivitis. Since the activatio...

OBJECTIVES This study aimed to assess and compare the levels of interleukin-1beta (IL-1β) and interleukin-6 (IL-6) in the crevicular fluid around healthy implants, implants with peri-implantitis, and healthy teeth. MATERIALS AND METHODS This study evaluated 16 dental implants in 8 patients (4 males and 4 females). These patients had at least one healthy implant and one implant with peri-impla...

Like other fluids of the human body, a gingival crevicular fluid (GCF) contains proteins, a diverse population of cells, desquamated epithelial cells, and bacteria from adjacent plaque. Proteomic tools have revolutionized the characterization of proteins and peptides and the detection of early disease changes in the human body. Gingival crevicular fluids (GCFs) are a very specific oral cavity f...