objective(s):the hippocampus has been implicated in pathophysiology of schizophrenia. prenatal stress is a contributing risk factor for a wide variety of neuropsychiatric diseases including schizophrenia. this study examined long-term effects of prenatal restraint stress on the stereological parameters in the cornu ammonis (ca) of adult male rats as an animal model of schizophrenia. materials a...

Sharp wave and associated fast oscillatory ripples (140-200 Hz) in the cornu ammonis 1 region are the most synchronous hippocampal patterns in the adult rat. Spike sequences associated with sharp waves are believed to play a critical role in transferring transient memories from the hippocampus to the neocortex and the emergence of superfast ripples is pathognostic in temporal lobe epilepsy. Sha...

Genetically targeted anatomical and behavioral characterization of the cornu ammonis 2 (CA2) subfield of the mouse hippocampus

BACKGROUND Magnetic resonance spectroscopy (MRS) has demonstrated consistent metabolic abnormalities in temporal lobe epilepsy. The reason for decreases in N-acetylated compounds are thought to be related to neuronal hippocampal cell loss as observed in hippocampal sclerosis. However, mounting evidence suggest that the N-acetylated compound decreases may be functional and reversible. OBJECTIV...

Children are at potential risk due to their intense use of mobile phones. We examined 8-week-old rats because this age of the rats is comparable with the preadolescent period in humans. The number of pyramidal neurons in the cornu ammonis of the Sprague Dawley male rat (8-weeks old, weighing 180-250 g) hippocampus following exposure to a 900 MHz (MHz) electromagnetic field (EMF) were examined. ...

GABAergic inhibition and particularly perisomatic inhibition play a crucial role in controlling the firing properties of large principal cell populations. Furthermore, GABAergic network is a key element in the therapy attempting to reduce epileptic activity. Here, we present a review showing the synaptic changes of perisomatic inhibitory neuronal subtypes in the hippocampus of temporal lobe epi...

background & aim: in traditional medicine, boswellia species gum resin known as frankincense or olibanum, has been administrated in elderly for enhancement of memory and also in pregnant women to increase memory and intelligence of progeny. however, it has been rarely scientifically documented so far. we have previously reported that maternal administration of frankincense during lactation ...

PURPOSE To identify changes in the embryology of the hippocampus responsible for its adult anatomy. METHODS Ten human fetal specimens ranging from 13 to 24 weeks' gestational age were examined with MR imaging. Dissections and histologic sections of 10 different specimens of similar ages were compared with MR imaging findings. RESULTS At 13 to 14 weeks' gestation, the unfolded hippocampus, o...

IT hlas been shown that after the injection of organisms into the general circulation of rabbits definite lesions are found in the nerve-cell lamina of the brain'. These lesions are necrotic, but all areas are not involved to the same degree. The fornix shows the maximum of damage; here the necrotic lesion is definitely ischwemic. In the cornu Ammonis the ischamia is somewhat less absolute, whi...