The development of carbon-monoxide-releasing molecules (CORMs) as pharmaceutical agents represents an attractive and safer alternative to administration of gaseous CO. Most CORMs developed to date are transition-metal carbonyl complexes. Although such CORMs have showed promising results in the treatment of a number of animal models of disease, they still lack the necessary attributes for clinic...

Corms and the above ground parts of the yellow meadow saffron (Colchicum luteum Baker) have been proposed for the isolation of colchicine and colchamine in our country. Corms are collected and stored in large quantities for the extraction which result in rapid depletion of the raw material sources. In order to investigate the effects of chitosan on germination and growth of corms of Colchicum l...

OBJECTIVE Carbon monoxide (CO) is a weak soluble guanylyl cyclase stimulator, leading to transient increases in cGMP and vasodilation. The aim of the present work was to measure the effect of CO-releasing molecules (CORMs) on the cGMP/nitric oxide (NO) pathway and to evaluate how selected CORMs affect NO-induced vasorelaxation. METHODS AND RESULTS Incubation of smooth muscle cells with some b...

Rule based reasoning and case based reasoning have emerged as two important and complementary reasoning methodologies in artificial intelligence (Al). This paper describes the approach for the development of CORMS AI, a decision support system which employs rule-based and case-based reasoning to assist NOAA’s Center for Operational Oceanographic Products and Services watch standing personnel in...

1. The orchid Tipularia discolor possesses two to five subterranean corms containing a high concentration of total non-structural carbohydrates (TNC). W e investigated the role of corms in the initiation of new growth following seasonal dormancy, in reproduction, and in the response of plants to artificial defoliation. 2. Severance of older corms (representing c. 3O0/0 of total corm biomass) in...

Objective—Carbon monoxide (CO) is a weak soluble guanylyl cyclase stimulator, leading to transient increases in cGMP and vasodilation. The aim of the present work was to measure the effect of CO-releasing molecules (CORMs) on the cGMP/nitric oxide (NO) pathway and to evaluate how selected CORMs affect NO-induced vasorelaxation. Methods and Results—Incubation of smooth muscle cells with some but...

Acyloxydiene-Fe(CO)3 complexes can act as enzyme-triggered CO-releasing molecules (ET-CORMs). Their biological activity strongly depends on the mother compound from which they are derived, i.e. cyclohexenone or cyclohexanedione, and on the position of the ester functionality they harbour. The present study addresses if the latter characteristic affects CO release, if cytotoxicity of ET-CORMs is...

IL-6/STAT3 pathway is involved in a variety of biological responses, including cell proliferation, differentiation, apoptosis, and inflammation. In our present study, we found that CO releasing molecules (CORMs) suppress IL-6-induced STAT3 phosphorylation, nuclear translocation and transactivity in endothelial cells (ECs). CO is a byproduct of heme degradation mediated by heme oxygenase (HO-1)....

Background Carbon monoxide (CO) is a signaling molecule that controls many physiological processes in mammalian tissues. CO gas activates sGC by 3–4-fold and exerts vasodilatory effects through elevation of cGMP. Certain transition metal carbonyls liberate CO in a controlled fashion and function as CO-releasing molecules (CORMs). Some of these agents have a variety of pharmacological effects an...

The possibility of a "post-antibiotic era" in the 21st century, in which common infections may kill, has prompted research into radically new antimicrobials. CO-releasing molecules (CORMs), mostly metal carbonyl compounds, originally developed for therapeutic CO delivery in animals, are potent antimicrobial agents. Certain CORMs inhibit growth and respiration, reduce viability, and release CO t...